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TranscriptomicsStructural and functional characterization of the N-terminus of Schizosaccharomyces pombe Cwf10
The spliceosome is a dynamic macromolecular machine that catalyzes the removal of introns from pre-mRNA to make mature message. Schizosaccharomyces pombe Cwf10 (homolog Saccharomyces cerevisiae Snu114 and of Human U5-116K), an integral member of the U5 snRNP, is a GTPase that shares sequence homolog...
ORGANISM(S): Schizosaccharomyces pombe 
2013-09-25 | E-GEOD-47573 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat arteries from animals with salt induced hypertensive disease results in over expression of matricellular genes in cerebral arteries
The Dahl salt-sensitive (S) rat model develops chronic hypertensive disease when fed a high salt diet that ultimately results in renal and heart failure, as well as prevalent cerebrovascular pathologies. Phenotypic changes in the cerebral vasculature are preceded by changes in gene expression, and ...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5488 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytes after treatment vehicle, isotype control antibody, TREM1 antibody, LPS, isotype control antibody plus LPS and TREM1 antibody plus LP to invesigate innate immune responses to TREM-1 activation
TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an immunoreceptor tyrosine-based activation motif (ITAM). TREM-1 activation by receptor cross-linking is pro-inflammatory, ...
ORGANISM(S): Homo sapiens 
2008-04-05 | E-GEOD-9988 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse atrioventricular junction gene expression at embryonic day 10.5-11.0
Goals of this study were to identify new candidates involved in the development of the Atrioventricular cushions in the mouse heart. Experiment Overall Design: The atrioventricular junction and ventricular region were dissected from 80 embryonic day 10.5-11.0, wild type, C57BL/6 mouse hearts. RNA w...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4903 | biostudies-arrayexpress
TranscriptomicsProgrammed cell senescence during embryonic development
Cellular senescence disables the proliferation of damaged cells and it is relevant for cancer and aging. Here, we show that cellular senescence occurs during mammalian embryonic development. Specifically, we have focused on the mouse regressing mesonephros and the endolymphatic sac of the inner ear....
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-49108 | biostudies-arrayexpress
UnknownEritoran attenuates tissue damage and inflammation in hemorrhagic shock/trauma.
Not available
S-EPMC10026379 | biostudies-literature
TranscriptomicsMechanical loading and gene expression - Microarray study
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | E-GEOD-50707 | biostudies-arrayexpress
UnknownNK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock.
Not available
S-EPMC6608053 | biostudies-literature
TranscriptomicsTranscription profiling of field-caught permethrin-resistant Anopheles gambiae shows over-expression of CYP6P3, a P450 that metabolizes pyrethroids
Field-caught permethrin-resistant Anopheles gambiae s.s. overexpress CYP6P3, a P450 that metabolizes pyrethroids
ORGANISM(S): Anopheles gambiae s.s. 
2009-01-17 | E-MTAB-52 | biostudies-arrayexpress
UnknownGasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis.
Not available
S-EPMC6579760 | biostudies-literature
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