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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
TranscriptomicsTranscription profiling of the Antarctic springtail Cryptopygus antarcticus to investigate cold hardening processes.
High group animals with supercooling point (SCP) above -15°C and selected low group animals with SCP below -15°C were prepared from Cryptopygus antarcticus collected from wet moss (Sanionia uncinata (Hedw.)) during the austral summer of 2005 at the British Antarctic Survey's research station at Rot...
ORGANISM(S): Cryptopygus antarcticus 
2008-09-01 | E-MEXP-1569 | biostudies-arrayexpress
TranscriptomicsGene expression of SCP-1 cells after incubation with conditioned medium of the breast carcinoma cell line MCF-7.
Disseminated tumor cells (DTCs) in the bone marrow can be detected in patients with solid tumors early on in disease progression. Via interaction with mesenchymal stromal cells (MSCs) these tumor cells may interfere with hematopoiesis. Using appropriate co-culture models, we investigated whether DTC...
ORGANISM(S): Homo sapiens 
2013-08-14 | E-GEOD-49858 | biostudies-arrayexpress
MetabolomicsStudy on the Hepatoprotection of Schisandra chinensis Caulis Ploysaccharides in nonalcoholic fatty liver disease in rats based on metabolomics

The aim of this study was to investigate the hepatoprotection of Schisandra chinensis Caulis polysaccharides (SCP) in the nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD) in rats. A total of 30 Wistar rats were randomly divided into control group (CON), model group...

2021-08-24 | MTBLS3194 | MetaboLights
UnknownSex-dependent impact of Scp-2/Scp-x gene ablation on hepatic phytol metabolism.
Not available
S-EPMC5697903 | biostudies-literature
TranscriptomicsSCP-mediated chlorophyll synthesis and Photosystem II assembly maintains nitrogen homeostasis in Synechocystis sp. PCC 6803
Small CAB-like proteins (SCPs) are single-helix light-harvesting-like proteins found in all organisms performing oxygenic photosynthesis. We investigated the function of these stress-induced proteins in the cyanobacterium Synechocystis sp. PCC 6803 by comparing a strain, which expresses SCPs constit...
ORGANISM(S): Synechocystis sp. PCC 6803 
2015-03-30 | E-GEOD-59371 | biostudies-arrayexpress
UnknownScp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat.
Not available
S-EPMC6033332 | biostudies-literature
ProteomicsDIA proteomics of dried blood spot proteins by sodium carbonate
We developed a simple and sensitive analysis method for dried blood spot (DBS) proteins by sodium carbonate precipitation (SCP). We aimed to removing large amounts of hydrophilic blood proteins such as hemoglobin, albumin, fibrinogen and transferrin in DBS using a simple pretreatment with sodium car...
ORGANISM(S): Homo Sapiens (human) 
2020-01-20 | PXD017185 | JPOST Repository
TranscriptomicsTranscription profiling of the Antarctic springtail Cryptopygus antarcticus kept at -15 to 2 degrees C to investigate cold tolerance
The ability of the Antarctic microarthropod, Cryptopygus antarcticus (Collembola, Isotomidae), to survive low temperatures has been well studied at the physiological level. These investigations have indicated the importance of the moulting process in conferring this ability. This study investigated ...
ORGANISM(S): Cryptopygus antarcticus 
2009-12-01 | E-MEXP-2262 | biostudies-arrayexpress
GenomicsBraf-mutant Schwann cells divert to a repair phenotype to induce congenital demyelinating neuropathy [SCP]
Braf-mutant Schwann cells divert to a repair phenotype to induce congenital demyelinating neuropathy [SCP]
PRJNA1090095 | ENA
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