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ProteomicsA Proteolytic Switch: USP5 controls SDE2 function via UBL-directed cleavage
Proteolytic processing is a critical regulatory mechanism in eukaryotic cells, yet the molecular identities and mechanisms underlying these events often remain elusive. Silencing Defective 2 (SDE2) is an essential human protein involved in multiple aspects of genome regulation, including DNA repair,...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD072107 | Pride
Hdx-ms Sde2 Usp5 Ubiquitin 
Proteomicsproteomics analysis of SDe2 cleavage in lysate fractions from Expi293 cells
SDE2, a highly conserved and essential gene required for genome maintenance, coordinates essential processes ranging from pre-mRNA splicing and ribosome biogenesis to DNA repair and replication stress response. It is expressed as a full-length precursor (SDE2FL,) bearing an N-terminal ULD, which is ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-24 | PXD064153 | Pride
Ubiquitin-like fusion proteins Sde2 Proteolysis 
GenomicsPoly(A) RNA sequencing of Silencing Defective 2 (SDE2) depletion in HeLa cells via siRNA
Poly(A) RNA sequencing of Silencing Defective 2 (SDE2) depletion in HeLa cells via siRNA
PRJNA599420 | ENA
UnknownInhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma.
Not available
S-EPMC12907901 | biostudies-literature
TranscriptomicsPoly(A) RNA sequencing of Silencing Defective 2 (SDE2) depletion in HeLa cells via siRNA
Pre-mRNA splicing is a complex and dynamic process that relies on the intricate coordination between a multitude of cis-elements and trans-acting factors. Here, we identify and characterize Silencing Defective 2 (SDE2) as a human RNA binding protein and trans-acting splicing-associated factor requir...
ORGANISM(S): Homo sapiens 
2021-01-01 | GSE143258 | GEO
TranscriptomicsUbiquitin-like processing of the conserved splicing regulator Sde2 promotes telomeric silencing and genome stability
Intron-containing gene expression in eukaryotes proceeds through the process of RNA splicing to generate protein-coding messenger RNAs (mRNAs). Herein a large and dynamic ribonucleoprotein complex — the spliceosome — removes non-coding introns from pre-mRNAs and joins exons. Spliceosomes must also e...
ORGANISM(S): Schizosaccharomyces pombe 
2017-09-22 | GSE97097 | GEO
UnknownPCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.
Not available
S-EPMC5131917 | biostudies-literature
UnknownSde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Not available
S-EPMC5753039 | biostudies-literature
UnknownSDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks.
Not available
S-EPMC7603486 | biostudies-literature
UnknownProteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells.
Not available
S-EPMC7380487 | biostudies-literature
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