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TranscriptomicsExpression data from SDH-disabled GIST
Pediatric GIST commonly harbors a disabled succinate dehydrogenase complex (SDH), which yields tumors with highly conserved genomes but characteristic epigenomic signatures. Mysteriously, nearly half of such SDH-deficient GIST, including tumors from Carney Triad patients, lack identifiable mutations...
ORGANISM(S): Homo sapiens 
2015-01-02 | E-GEOD-56670 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis for differential gene expression in M1-SDHHbtail
A total of 215 gene were found to be differentially expressed; 90 of them were up regulated and 125 genes were down regulated. Most notably the functional categories that were affected include Virulence genes, carbohydrate genes and lipid synthesis genes. Some of the virulence genes were down regula...
ORGANISM(S): Streptococcus pyogenes 
2011-06-15 | E-GEOD-15231 | biostudies-arrayexpress
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
ProteomicsMEF cell proteome quantification
Global quantification of the dynamics of proteome and lysine succinylation proteome upon the loss of SDH in MEF cells.
ORGANISM(S): Mus musculus (Mouse) 
2018-02-16 | PXD007874 | Pride
Sdh loss Protein quantification 
GenomicsSDH deficient renal tumours RNA
Succinate dehydrogenase (SDH) deficient renal cancers are a rare and understudied subtype of renal cancer. As such they represent an unmet need in kidney cancer research. Here, we seek to describe the genomics and transcriptomics of SDH deficient renal cancers by sequencing five such tumours.
EGAS00001004103 | EGA
TranscriptomicsGene expression analysis of SDH-deficient immortalized kidney epithelial cells
Succinate dehydrogenase (SDH) is a mitochondrial protein complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Loss-of-function mutations in any of the SDH genes are associated with susceptibility to develop neu-roendrocrine neoplasms and renal cell carcinom...
ORGANISM(S): Mus musculus 
2016-01-22 | E-MTAB-4349 | biostudies-arrayexpress
GenomicsSDH deficient renal tumours WGS
Succinate dehydrogenase (SDH) deficient renal cancers are a rare and understudied subtype of renal cancer. As such they represent an unmet need in kidney cancer research. Here, we seek to describe the genomics and transcriptomics of SDH deficient renal cancers by sequencing five such tumours. We doc...
EGAS00001004102 | EGA
ProteomicsProteome, acetylome, and succinylome analysis of control and SDH-loss imCCs and iMEFs as models of SDH-loss pheochromocytoma and paraganglioma
The tricarboxylic acid (TCA) cycle and electron transport chain (ETC) are key metabolic pathways required for cellular energy production. While loss of components in these pathways typically impairs cell survival, such defects can paradoxically promote tumorigenesis in certain cell types. One such e...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD066626 | Pride
Succinylation Proteomics Acetylation Paraganglioma Pheochromocytoma Succinate dehydrogenase Acylation 
GenomicsAltered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
PRJNA420090 | ENA
GenomicsOryza sativa Japonica Group strain:plant | isolate:Nil-sdh | breed:plant | cultivar:Japonica rice
Transcriptome sequencing of the Nil-sdh mutant in japonica rice
PRJNA1171578 | ENA
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