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TranscriptomicsMicroarray analysis for differential gene expression in M1-SDHHbtail
A total of 215 gene were found to be differentially expressed; 90 of them were up regulated and 125 genes were down regulated. Most notably the functional categories that were affected include Virulence genes, carbohydrate genes and lipid synthesis genes. Some of the virulence genes were down regula...
ORGANISM(S): Streptococcus pyogenes 
2011-06-15 | E-GEOD-15231 | biostudies-arrayexpress
ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD053722 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia 
ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD047175 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia. 
ProteomicsProteome, acetylome, and succinylome analysis of control and SDH-loss imCCs and iMEFs as models of SDH-loss pheochromocytoma and paraganglioma
The tricarboxylic acid (TCA) cycle and electron transport chain (ETC) are key metabolic pathways required for cellular energy production. While loss of components in these pathways typically impairs cell survival, such defects can paradoxically promote tumorigenesis in certain cell types. One such e...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD066626 | Pride
Succinylation Proteomics Acetylation Paraganglioma Pheochromocytoma Succinate dehydrogenase Acylation 
UnknownSuccinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome.
Not available
S-EPMC5776069 | biostudies-literature
TranscriptomicsGene expression analysis of SDH-deficient immortalized kidney epithelial cells
Succinate dehydrogenase (SDH) is a mitochondrial protein complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Loss-of-function mutations in any of the SDH genes are associated with susceptibility to develop neu-roendrocrine neoplasms and renal cell carcinom...
ORGANISM(S): Mus musculus 
2016-01-22 | E-MTAB-4349 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pheochromocytomas of various genetic origins
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes: RET, VHL, NF1, and subunits B, C and D of succinate dehydrogenase (SDH). The proteins encoded by these multiple genes regulate distinct functions. To identify molecula...
ORGANISM(S): Homo sapiens 
2007-06-21 | E-GEOD-2841 | biostudies-arrayexpress
GenomicsAltered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
PRJNA420090 | ENA
GenomicsAltered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood. A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase (SDH)-deficiency and global DNA hyper-methylation. Here ...
ORGANISM(S): Homo sapiens 
2019-10-16 | GSE107447 | GEO
TranscriptomicsSimilar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas
The similarity in gene-expression profiles suggest that PGL2, like SDHD, is involved in the functionality of the SDH complex, and that tumor formation in these three subgroups involves the same pathways as in SDH linked paragangliomas. We were not able to clarify the identity of PGL2 on 11q13. The l...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-12921 | biostudies-arrayexpress
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