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ProteomicsProteome, acetylome, and succinylome analysis of control and SDH-loss imCCs and iMEFs as models of SDH-loss pheochromocytoma and paraganglioma
The tricarboxylic acid (TCA) cycle and electron transport chain (ETC) are key metabolic pathways required for cellular energy production. While loss of components in these pathways typically impairs cell survival, such defects can paradoxically promote tumorigenesis in certain cell types. One such e...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD066626 | Pride
Succinylation Proteomics Acetylation Paraganglioma Pheochromocytoma Succinate dehydrogenase Acylation 
TranscriptomicsExpression data from SDH-disabled GIST
Pediatric GIST commonly harbors a disabled succinate dehydrogenase complex (SDH), which yields tumors with highly conserved genomes but characteristic epigenomic signatures. Mysteriously, nearly half of such SDH-deficient GIST, including tumors from Carney Triad patients, lack identifiable mutations...
ORGANISM(S): Homo sapiens 
2015-01-02 | E-GEOD-56670 | biostudies-arrayexpress
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
ProteomicsMEF cell proteome quantification
Global quantification of the dynamics of proteome and lysine succinylation proteome upon the loss of SDH in MEF cells.
ORGANISM(S): Mus musculus (Mouse) 
2018-02-16 | PXD007874 | Pride
Sdh loss Protein quantification 
TranscriptomicsGene expression analysis of SDH-deficient immortalized kidney epithelial cells
Succinate dehydrogenase (SDH) is a mitochondrial protein complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Loss-of-function mutations in any of the SDH genes are associated with susceptibility to develop neu-roendrocrine neoplasms and renal cell carcinom...
ORGANISM(S): Mus musculus 
2016-01-22 | E-MTAB-4349 | biostudies-arrayexpress
UnknownA Mathematical Exploration of SDH-b Loss in Chromaffin Cells.
Not available
S-EPMC11906556 | biostudies-literature
TranscriptomicsTranscription profiling of human pheochromocytomas of various genetic origins
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes: RET, VHL, NF1, and subunits B, C and D of succinate dehydrogenase (SDH). The proteins encoded by these multiple genes regulate distinct functions. To identify molecula...
ORGANISM(S): Homo sapiens 
2007-06-21 | E-GEOD-2841 | biostudies-arrayexpress
TranscriptomicsSimilar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas
The similarity in gene-expression profiles suggest that PGL2, like SDHD, is involved in the functionality of the SDH complex, and that tumor formation in these three subgroups involves the same pathways as in SDH linked paragangliomas. We were not able to clarify the identity of PGL2 on 11q13. The l...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-12921 | biostudies-arrayexpress
GenomicsAltered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
PRJNA420090 | ENA
UnknownCharacterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma.
Not available
S-EPMC5814199 | biostudies-literature
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