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ProteomicsSDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous termin...
ORGANISM(S): Homo sapiens (Human) 
2022-05-10 | PXD033059 | Pride
Cancer Isodtb Sdr enzymes Alkynylcarbinol 
UnknownSDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Not available
S-EPMC9090334 | biostudies-literature
UnknownHomologous relationship between FabG involved in fatty acid biosynthesis and SDR on chromosome II in the multi-chromosome pathogen Vibrio anguillarum.
Not available
S-EPMC11906770 | biostudies-literature
UnknownFunctional Characterization and Synthetic Application of Is2-SDR, a Novel Thermostable and Promiscuous Ketoreductase from a Hot Spring Metagenome.
Not available
S-EPMC9603792 | biostudies-literature
UnknownCrystallographic structure determination and analysis of a potential short-chain dehydrogenase/reductase (SDR) from multi-drug resistant Acinetobacter baumannii.
Not available
S-EPMC10449147 | biostudies-literature
GenomicsProfiling trace organic chemical biotransformation genes, enzymes and associated bacteria in microbial model communities
Profiling trace organic chemical biotransformation genes, enzymes and associated bacteria in microbial model communities
PRJEB74141 | ENA
UnknownPredicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis.
Not available
S-EPMC2279256 | biostudies-literature
UnknownEscherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes.
Not available
S-EPMC7973133 | biostudies-literature
UnknownBacterial Enzymes Catalyzing the Synthesis of 1,8-Dihydroxynaphthalene, a Key Precursor of Dihydroxynaphthalene Melanin, from Sorangium cellulosum.
Not available
S-EPMC5930340 | biostudies-literature
UnknownFlexible regulation of DNA displacement reaction through nucleic acid-recognition enzyme and its application in keypad lock system and biosensing.
Not available
S-EPMC5577262 | biostudies-literature
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