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ProteomicsPhosphoproteomics-directed manipulation reveals SEC22B as an hepatocellular signaling node governing metabolic actions of glucagon
The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmocotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little of how glucagon exerts its pleiotropic metabolic actions. Given that the liver is a chief site of action,...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-29 | PXD049203 | Pride
Proteomcis Liver Sec22b Co-immunoprecipitation 
ProteomicsPhosphoproteomics-directed manipulation reveals SEC22B as an hepatocellular signaling node governing metabolic actions of glucagon
The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmocotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little of how glucagon exerts its pleiotropic metabolic actions. Given that the liver is a chief site of action,...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-29 | PXD049186 | Pride
Sec22b Liver Mass spectrometry Glucagon Phosphoproteomics 
UnknownSec22b is a critical and nonredundant regulator of plasma cell maintenance.
Not available
S-EPMC9926242 | biostudies-literature
GenomicsRNAsequencing of plasma cells generated ex vivo upon 2 days of LPS stimulation on WT and Sec22B-KO plasma cells
RNAsequencing of plasma cells generated ex vivo upon 2 days of LPS stimulation on WT and Sec22B-KO plasma cells
PRJNA778822 | ENA
UnknownA Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation.
Not available
S-EPMC5539946 | biostudies-literature
UnknownMorphological and functional association of Sec22b/ERS-24 with the pre-Golgi intermediate compartment.
Not available
S-EPMC25179 | biostudies-literature
UnknownQa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B.
Not available
S-EPMC10663520 | biostudies-literature
UnknownSec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites.
Not available
S-EPMC10550925 | biostudies-literature
UnknownPhosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon.
Not available
S-EPMC11436942 | biostudies-literature
UnknownLegionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b.
Not available
S-EPMC3164831 | biostudies-literature
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