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ProteomicsLipid Scrambling Pathways in the Sec61 Translocon Complex
Maintenance of cellular homeostasis and functionality requires rapid translocation of newly synthesized lipids across the membrane leaflets of the endoplasmic reticulum (ER) where majority of cellular lipid biosynthesis takes place. This process is facilitated without the need for ATP by specific me...
ORGANISM(S): Ovis canadensis sierrae 
2025-05-26 | PXD062310 | Pride
Translocon complex Sec61 
ProteomicsA novel translocon for biogenesis of multi-pass membrane proteins
A novel 370 kDa translocon comprising Sec61 and five accessory factors acting co-translationally with ribosomes to fold and insert multi-pass membrane proteins was identified, purified and analyzed structurally by single particle cryo-EM and cross-linking mass spectrometry. The purified ribosome-tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-08 | MSV000084065 | MassIVE
ProteomicsSND3 is the membrane insertase within a distinct SEC61 translocon complex
During the biogenesis of most eukaryotic integral membrane proteins (IMPs), transmembrane domains are inserted into the endoplasmic reticulum membrane by a dedicated insertase or the SEC61 translocon. The SRP-independent (SND) pathway is the least understood route into the membrane, despite catering...
ORGANISM(S): Chaetomium thermophilum 
2025-09-24 | PXD060914 | Pride
Proteomics Multipass translocon Membrane insertase Snd3 
UnknownLipid Scrambling Pathways in the Sec61 Translocon Complex.
Not available
S-EPMC12082634 | biostudies-literature
UnknownThe Sec61 translocon limits IRE1α signaling during the unfolded protein response.
Not available
S-EPMC5449187 | biostudies-literature
OtherTranslocon remodeling during protein synthesis at the ER
Protein biogenesis at the endoplasmic reticulum (ER) is coordinated by the Sec61 translocon whose dynamic subunit composition is essential for maintaining a functional proteome. How nascent secretory and membrane proteins recruit accessory factors to the translocon, and what controls the interplay b...
ORGANISM(S): Homo sapiens 
2025-08-30 | GSE297497 | GEO
UnknownSND3 is the membrane insertase within a distinct SEC61 translocon complex.
Not available
S-EPMC12572126 | biostudies-literature
GenomicsTranslocon remodeling during protein synthesis at the ER
Translocon remodeling during protein synthesis at the ER
PRJNA1265091 | ENA
UnknownMycolactone subverts immunity by selectively blocking the Sec61 translocon.
Not available
S-EPMC5154940 | biostudies-literature
UnknownStructural and functional profiling of the lateral gate of the Sec61 translocon.
Not available
S-EPMC4140938 | biostudies-literature
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