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ProteomicsLipid Scrambling Pathways in the Sec61 Translocon Complex
Maintenance of cellular homeostasis and functionality requires rapid translocation of newly synthesized lipids across the membrane leaflets of the endoplasmic reticulum (ER) where majority of cellular lipid biosynthesis takes place. This process is facilitated without the need for ATP by specific me...
ORGANISM(S): Ovis canadensis sierrae 
2025-05-26 | PXD062310 | Pride
Translocon complex Sec61 
ProteomicsEffect of Sec61 inhibitor mycolactone on the proteome of the MutuDC dendritic cell line
Here we used a newly identified Sec61 blocker, mycolactone, to analyze Sec61 contribution to antigen cross presentation, ERAD and transport of internalized antigens into the cytosol in dendritic cells. Shotgun proteomics were used to asses the broad-ranging effects of Sec61 blockade on dendritic cel...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-11 | PXD006103 | Pride
Mouse mutudc dendritic mycolactone sec61 ms/ms lfq 
ProteomicsEffect of Sec61 inhibitor mycolactone on the proteome of the MED17.11 neuronal cell line
Mycolactone is a mycobacteria-derived macrolide that blocks the biogenesis of a large array of secreted and transmembrane proteins through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated Sec61 block...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-26 | PXD007770 | Pride
Sec61 Mycolactone Sensory neurons 
ProteomicsMolecular view of ER membrane remodeling by the Sec61/TRAP translocon
Cross-linking mass spectrometry of the sheep Sec61-TRAP complex
ORGANISM(S): Ovis Aries (ncbitaxon:9940) 
MSV000090438 | MassIVE
ProteomicsSbh1/Sec61-beta is a specific signal peptide receptor within the Sec61 channel
In eukaryotes, protein secretion begins with protein translocation through the universally conserved Sec61 channel into the endoplasmic reticulum (ER). Its -subunit, Sbh1 in yeast, enhances ER import of proteins with specific suboptimal signal peptides by an unknown mechanism. The Sbh1 cytosolic N-t...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-09-07 | PXD081202 | Pride
Xl-ms sbh1 signal peptides sec61 channel 
ProteomicsA light-resuming strategy as a screening method for Sec61 inhibitors down-modulating PD-L1 expression
The perturbation of protein translocation into the secretory pathway using Sec61 translocon inhibitors is a novel and promising strategy for tackling many pathological situations, including cancer and viral infections. However, a highly sensitive and direct screening platform for selecting Sec61 inh...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD063288 | Pride
Sec61 Secretory pathway Pd-l1 
UnknownComplexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex.
Not available
S-EPMC8147068 | biostudies-literature
ProteomicsA novel translocon for biogenesis of multi-pass membrane proteins
A novel 370 kDa translocon comprising Sec61 and five accessory factors acting co-translationally with ribosomes to fold and insert multi-pass membrane proteins was identified, purified and analyzed structurally by single particle cryo-EM and cross-linking mass spectrometry. The purified ribosome-tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-08 | MSV000084065 | MassIVE
ProteomicsSND3 is the membrane insertase within a distinct SEC61 translocon complex
During the biogenesis of most eukaryotic integral membrane proteins (IMPs), transmembrane domains are inserted into the endoplasmic reticulum membrane by a dedicated insertase or the SEC61 translocon. The SRP-independent (SND) pathway is the least understood route into the membrane, despite catering...
ORGANISM(S): Chaetomium thermophilum 
2025-09-24 | PXD060914 | Pride
Proteomics Multipass translocon Membrane insertase Snd3 
UnknownChaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.
Not available
S-EPMC5946456 | biostudies-literature
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