Sort   by:  
 Page size 
ProteomicsLC-MS/MS identification of Mycolactone protein targets
Mycolactone is a diffusible macrolide produced by the skin pathogen Mycobacterium ulcerans that suppresses the development of protective immunity against Buruli ulcer disease. In this proteomics study we aimed to identify proteins of which the expression levels changed upon mycolactone treatment. Ju...
ORGANISM(S): Homo sapiens (Human) 
2016-11-04 | PXD002971 | Pride
Mycolactone Silac Jurkat t-cells 
ProteomicsEffect of Sec61 inhibitor mycolactone on the proteome of the MED17.11 neuronal cell line
Mycolactone is a mycobacteria-derived macrolide that blocks the biogenesis of a large array of secreted and transmembrane proteins through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated Sec61 block...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-26 | PXD007770 | Pride
Sec61 Mycolactone Sensory neurons 
ProteomicsEffect of Sec61 inhibitor mycolactone on the proteome of the MutuDC dendritic cell line
Here we used a newly identified Sec61 blocker, mycolactone, to analyze Sec61 contribution to antigen cross presentation, ERAD and transport of internalized antigens into the cytosol in dendritic cells. Shotgun proteomics were used to asses the broad-ranging effects of Sec61 blockade on dendritic cel...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-11 | PXD006103 | Pride
Mouse mutudc dendritic mycolactone sec61 ms/ms lfq 
ProteomicsMycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: A new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection.
The drivers of tissue necrosis in Mycobacterium ulcerans infection (Buruli ulcer disease) have historically been ascribed solely to the cytotoxic action of the diffusible endotoxin, mycolactone. However, clinical evidence supporting a strong vascular contribution to disease aetiology has, until rece...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD037489 | Pride
Sec61 translocon. Tissue necrosis Proteomics Buruli ulcer disease Mycolactone 
TranscriptomicsLPS stimulated murine RAW264.7 cells, incubated with DMSO carrier or mycolactone
Translational profiling of RAW264.7 cells stimulated with LPS in the presence and absence of 125ng/ml mycolactone: polysomal and subpolysomal RNA isolated by sucrose gradient centrifugation to determine the effect of mycolactone on translation during a proinflammatory response
ORGANISM(S): Mus musculus 
2018-03-21 | GSE103002 | GEO
UnknownMycolactone as Analgesic: Subcutaneous Bioavailability Parameters.
Not available
S-EPMC6473063 | biostudies-literature
UnknownRecombinant Antibodies against Mycolactone.
Not available
S-EPMC6628451 | biostudies-literature
UnknownThe potent effect of mycolactone on lipid membranes.
Not available
S-EPMC5779694 | biostudies-literature
Genomics
Staphylococcus Co-culture with Mycolactone
PRJNA673874 | ENA
Genomics
Transcriptome of mycolactone resistant cells
PRJNA639501 | ENA
Sort   by:  
 Page size