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TranscriptomicsExpression data from MDA-MB-231 parental and xenograft tumor cells treated with Smac mimetic SM-164.
Small-molecule Smac mimetics target inhibitor of apoptosis (IAP) proteins to induce TNFα-dependent apoptosis in cancer cells and several Smac mimetics have been advanced into clinical development as a new class of anticancer drugs. However, preclinical studies have shown that only a small subset of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-33827 | biostudies-arrayexpress
ProteomicsStructural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6
Certain Inhibitors of apoptosis (IAP) family members are sentinel proteins preventing untimely cell death by inhibiting caspases. Antagonists including second mitochondria-derived activator of caspase (SMAC) regulate IAPs, driving cell death. Baculoviral IAP repeat-containing protein 6 (BIRC6), a gi...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD039954 | Pride
Ap-ms Birc6 Structural biology Cell death Ubiquitomics Biochemistry 
UnknownDiscovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.
Not available
S-EPMC3989805 | biostudies-literature
UnknownHeat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis.
Not available
S-EPMC5422968 | biostudies-literature
ProteomicsSMAC mimetics regulate Th17 differentiation, function and physiology via the non-canonical NFkB pathway
TMT 10-plex proteome analysis of murine CD4+ T cells differentiated towards a Th17 lineage in the presence of a SMAC mimetic
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000082955 | MassIVE
ProteomicsStructural basis for how sMAC is packaged for clearance
In this study, we used bottom-up proteomics and cross-linking MS (XL-MS) to study the composition and structure of soluble membrane attack complex (sMAC). For bottom-up proteomics sMAC was digested using trypsin and analyzed on Orbitrap Fusion Lumos. For the cross-linking analysis sMAC was cross-lin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-25 | MSV000087092 | MassIVE
TranscriptomicsMicroarray analysis of in-vitro differentiated murine Th17 cells in the presence of the smac mimetic AT406, or DMSO as control, and undifferentiated naive CD4 T cells.
Transcriptome analysis to investigate the effects of the smac mimetic AT406 on the differentiation of murine Th17 cells compared to DMSO controls, and to investigate the transriptome of murine Th17 cells compared to control undifferentiated naive CD4 T cells.
ORGANISM(S): Mus musculus 
2019-08-15 | E-MTAB-7894 | biostudies-arrayexpress
UnknownCaspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis.
Not available
S-EPMC7714407 | biostudies-literature
UnknownEffect of Smac in combination with cisplatin on esophageal cancer cell line ECA109.
Not available
S-EPMC4694360 | biostudies-literature
TranscriptomicsmRNAseq of human sputum macrophages and alveolar-like monocyte-derived macrophages of healthy controls and NSAID-exacerbated respiratory disease (N-ERD) patients
NSAID-exacerbated respiratory disease (N-ERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. N-ERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-stero...
ORGANISM(S): Homo sapiens 
2020-06-30 | E-MTAB-7965 | biostudies-arrayexpress
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