Secretory granules

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Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht (1)
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Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis Department of Cell Biology & Physiology, Washington University, St. Louis (1)
Walter Brendel Center of Experimental Medicine Institute of Cardiovascular Physiology and Pathophysiology Biomedizinisches Centrum München Ludwig-Maximilians-Universität Großhaderner Str. 9 82152 Planegg-Martinsried GERMANY (1)
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Proteomic analysis of secretory granules in dopaminergic neurons of Parkinson`s disease

Parkinson disease (PD) is the second most common age-related neurodegenerative disorder, which is related to neurotransmitter secretion impartment and the dysfunction of vesicle transport. Secretory granules (SGs) are a class of intracellular vesicles different from synaptic vesicles (SVs) in neuron...

ORGANISM(S): Homo sapiens (Human)

2021-08-26 | PXD023937 | Pride

Signaling from the secretory granule to the nucleus: Uhmk1 and PAM

Neurons and endocrine cells package peptides in secretory granules (large dense core vesicles; LDCVs) for storage and stimulated release. Studies of PAM, an essential secretory granule membrane enzyme, revealed a pathway that can relay information from secretory granules to the nucleus, resulting i...

ORGANISM(S): Mus musculus

2010-07-29 | E-GEOD-22509 | biostudies-arrayexpress

Contemporary understanding of the secretory granules in human eosinophils.

Not available

S-EPMC6013358 | biostudies-literature

Proteomics of Enriched Insulin Secretory Granules Fractionated by Size Exclusion Chromotography

Hybrid insulin peptides (HIPs) form in pancreatic beta-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs, which have been confidently identified in pancreatic islets by mass spectrometry, are targeted by CD4 T cells in subjects with Type 1 Diabetes (T...

ORGANISM(S): Mus musculus (Mouse)

2023-11-16 | PXD032664 | Pride

Beta cell Proteins Insulin secretory granule Proteases

Tethering forces of secretory granules measured with optical tweezers.

Not available

S-EPMC2576405 | biostudies-literature

Characterization of the proteome of human blood platelet sercretory granules using gas-phase fractionation (GPF)

We performed an extensive qualitative characterization of the platelet granule proteome using subcellular fractionation followed by mass spectrometry analysis and functional annotation. Platelets were isolated from whole blood by centrifugation and their level of purity was tested by microscopic ins...

ORGANISM(S): Homo sapiens (Human)

2014-03-06 | PXD000618 | Pride

Platelet Secretory granules Gpf4

GGA function is required for maturation of neuroendocrine secretory granules.

Not available

S-EPMC1440831 | biostudies-literature

Not all secretory granules are created equal: Partitioning of soluble content proteins.

Not available

S-EPMC1761688 | biostudies-literature

Association with nitric oxide synthase on insulin secretory granules regulates glucokinase protein levels.

Not available

S-EPMC3434526 | biostudies-literature