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MetabolomicsA multi-omics approach reveals functions of Secretory Carrier-Associated Membrane Proteins in wood formation of Populus trees
Secretory Carrier-Associated Membrane Proteins (SCAMPs) are highly conserved proteins that are involved in membrane trafficking. An integrated approach was taken to elucidate function of SCAMPs in wood formation of Populus trees. The metabolomics analyses were performed in woody tissues of transgeni...
2018-01-08 | MTBLS478 | MetaboLights
MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
TranscriptomicsCrebA is a major and direct regulator of secretory pathway gene expression
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Drosophila melanogaster 
2010-10-18 | E-GEOD-23346 | biostudies-arrayexpress
TranscriptomicsThe CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Homo sapiens 
2010-10-18 | E-GEOD-23349 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype
This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory respon...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78141 | biostudies-arrayexpress
TranscriptomicsSpatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occured in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans-side ...
ORGANISM(S): Homo sapiens 
2011-05-04 | E-GEOD-28464 | biostudies-arrayexpress
GenomicsThe transcriptional responses of C. glutamicum to the secretory production of two different heterologous proteins
The transcriptional responses of C. glutamicum to the secretory production of two different heterologous proteins
PRJNA590712 | ENA
ProteomicsExcretory-secretory proteome of nematode Heligmosomoides polygyrus developed in colitic conditions
The aim of the study was to evaluate excretory-secretory protein set produced by nematode H. polygyrus L4 stage male and female developed in colitic milienu. Mass spectrometry was used to identify proteins. OmicsBox was used to investigate the functions of the discovered proteins.
ORGANISM(S): Heligmosomoides polygyrus bakeri 
2023-10-24 | PXD041516 | Pride
Lc-ms/ms Nematode Heligmosomoides polygyrus bakeri Excretory-secretory products Colitis 
GenomicsSecretory pathway differences between HEK293 and CHO enable rescue of difficult to express human proteins
Secretory pathway differences between HEK293 and CHO enable rescue of difficult to express human proteins
PRJNA662582 | ENA
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