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ProteomicsTXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
Entry and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here we show that cells entering quiescence selectively target plasma membrane-resident AA transpo...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066527 | Pride
Nutrient transporter Hect-type ubiquitin ligase Ppxy Quiescence Arrestin Endocytosis 
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
ModelsMorpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
Morpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
2020-11-27 | 759 | FAIRDOMHub
UnknownPolygenic Risk Scores and HLA Class II Variants are Biomarkers of Corticosteroid Response in Childhood Nephrotic Syndrome.
Not available
S-EPMC12443051 | biostudies-literature
UnknownThe Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1.
Not available
S-EPMC11323209 | biostudies-literature
UnknownUniversal DNA methylation age across mammalian tissues.
Not available
S-EPMC10501909 | biostudies-literature
UnknownDefining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.
Not available
S-EPMC6602051 | biostudies-literature
UnknownDNA methylation networks underlying mammalian traits.
Not available
S-EPMC11180965 | biostudies-literature
UnknownFungal Planet description sheets: 469-557.
Not available
S-EPMC5315290 | biostudies-literature
UnknownEffects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT.
Not available
S-EPMC11873788 | biostudies-literature
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