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Astrocyte Fabp7 modulates seizure threshold and activity-dependent gene expression in mouse brain
Differential Circadian Time Modulates of Dentate Gyrus and CA1 Excitation-Inhibition Balance and Seizure Threshold.
The circadian rhythm modulates seizure threshold and neuronal excitability. Seizures in temporal lobe epilepsy are more likely to occur during the diurnal phase compared to the nocturnal phase. However, the intrinsic excitability of dentate gyrus granule cells and the state of synaptic transmission ...
ORGANISM(S): Mus musculus 
2026-01-26 | GSE317534 | GEO
Patients with epilepsy often experience increased frequency of seizures at night. Given the crucial role glial cells play in modulating neuronal excitability, we hypothesize that circadian changes in glia may affect changes in seizure threshold. Fatty acid binding protein 7 (Fabp7) is expressed in b...
ORGANISM(S): Mus musculus 
2024-11-06 | GSE271985 | GEO
ntracranial electroencephalography (EEG) is commonly used to study epileptogenesis and epilepsy in experimental models. Chronic gliosis and neurodegeneration at the injury site are known to be associated with surgically implanted electrodes in both humans and experimental models. Currently, however,...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021554 | Pride

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
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