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MetabolomicsPolyphenolic Profiling of Plants and Edible Mushrooms to Aid Characterizing Polyphenol Oxidase Selectivity

Polyphenol oxidases are important metalloenzymes that catalyze the oxidation of polyphenols. Organisms can contain multiple isoenzymes whose possible different functionality is not understood. Moreover, their substrate preference is still unexplored, and a working hypothesis assumes their specifi...

2025-08-07 | MTBLS8782 | MetaboLights
ProteomicsProteome-wide profiling of the selectivity of diverse electrophiles
Targeted covalent inhibitors (TCIs) are established as powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine. Competitive, residue-specific proteomics has been instrumental to streamline covalent drug discovery targeting cysteine. Several pr...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2025-08-09 | PXD024454 | Pride
Covalent inhibitors Chemical proteomics Activity-based protein profiling Isodtb-abpp 
MetabolomicsHigh-throughput carotenoid profiling using multivariate curve resolution (Stability of isoprenoids in grape extract)
We present automated data analysis of high throughput high-performance liquid chromatography with diode array detection (HPLC-DAD) data using multivariate curve resolution. This technique provides spectra and elution profiles of all UV-Vis active compounds present in the mixture. The specifics of us...
2014-07-01 | MTBLS85 | MetaboLights
ProteomicsOn-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
On-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-24 | MSV000089122 | MassIVE
ProteomicsDiscovery of dedicated EPHA2 inhibitors - Medicinal chemistry meets chemical proteomics
The receptor tyrosine kinase EPHA2 has gained interest as therapeutical drug target in cancer and infectious diseases in the past years. However, EPHA2 research and EPHA2 based therapies have been hampered by the lack of selective small molecule EPHA2 inhibitors. We report on the synthesis and evalu...
ORGANISM(S): Homo sapiens (Human) 
2017-05-30 | PXD006193 | Pride
Eph receptor Drug discovery Selectivity profiling Inhibitors Chemical proteomics 
GenomicsHigh-resolution Ribosome Profiling Reveals Translational Selectivity in Bovine Preimplantation Embryo Development
High-resolution Ribosome Profiling Reveals Translational Selectivity in Bovine Preimplantation Embryo Development
PRJNA805180 | ENA
ProteomicsKinome-profiling enabled discovery of a LATS1/2 inhibitor with wound healing potential
System-level mapping of kinase inhibitors polypharmacology can uncover opportunities for drug repurposing and identify starting points for medicinal chemistry campaigns aimed at novel targets. Here, we describe a large-scale profiling of 257 kinase inhibitors that revealed domains of promiscuity, po...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD073488 | Pride
Human Proteomics Kinase selectivity profiling Kinase inhibitor 
GenomicsRules governing translation selectivity under limiting ribosome availability
Rules governing translation selectivity under limiting ribosome availability
PRJNA513511 | ENA
UnknownTargeted kinase selectivity from kinase profiling data.
Not available
S-EPMC4025760 | biostudies-literature
ProteomicsThermal proteome profiling reveals distinct target selectivity for differentially oxidized oxysterols
The dataset contains mass spectrometric raw data from Thermal Proteomic Profiling experiments aimed to identify the protein targets of three A- and B-ring oxidized sterols (cholestane-3beta,5alfa,6beta-triol (CT), 7keto-cholesterol (7-KC), 4beta-hydroxycholesterol (4beta-HC) ) and a side-chain oxidi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-16 | MSV000089661 | MassIVE
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