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TranscriptomicsKnockout of the selenocysteine tRNA (Trsp) gene in mouse macrophage
Comparative analysis of gene expression in bone marrow-derived macrophages (BMDM) from trsp knockout mice (Trspfl/fl-LysM-Cre+/-) and Control (Trspfl/fl-LysM-Cre-/-) mice. Selenium, a micronutrient whose deficiency in the diet causes immune dysfunction and inflammatory disorders, exerts its physio...
ORGANISM(S): Mus musculus 
2009-12-21 | E-GEOD-15610 | biostudies-arrayexpress
GenomicsSerRS mediates translational readthrough of through engagement of the selenocysteine incorporation machinery
SerRS mediates translational readthrough of through engagement of the selenocysteine incorporation machinery
PRJNA851750 | ENA
Genomicsselenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis
selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis
PRJNA1129129 | ENA
ProteomicsSite-Selective Photocatalytic Functionalization of Peptides and Proteins at Selenocysteine
The importance of modified peptides and proteins for applications in drug discovery, and for illuminating biological processes at the molecular level, has fueled a demand for efficient methods that facilitate the precise modification of these biomolecules. Herein, we describe the development of a ph...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD037525 | Pride
Selenocysteine Modification 
OtherSerRS mediates translational readthrough of through engagement of the selenocysteine incorporation machinery
Translational readthrough of UGA stop codons by selenocysteine-specific tRNAs (tRNASec) provide the basis for selenoprotein biosynthesis. Seryl-tRNA synthetase (SerRS) charges tRNASec with serine, which is modified into selenocysteine, and delivered to the ribosome by a designated elongation factor ...
ORGANISM(S): Homo sapiens 
2026-06-11 | GSE206674 | GEO
ProteomicsQuantitative Proteomics Reveals UGA-independent Mis-incorporation of Selenocysteine throughout Escherichia coli Proteome
LC-MS/MS based shotgun proteomics data of E. coli grew in standard M9 minimal medium, sulfur-depleted medium and selenite medium. We detected selenocysteine mis-incorporation in selenite group and compared its proteome changes with M9 and sulfur-depleted group. Files beginning with letter M, N and S...
ORGANISM(S): Escherichia Coli 
2020-10-06 | MSV000086241 | MassIVE
Genomicsselenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis [Xenograft Human]
selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis [Xenograft Human]
PRJNA1129142 | ENA
TranscriptomicsSeryl-tRNA synthetase promotes translational readthrough via mRNA binding by involving the selenocysteine incorporation machinery
Translational readthrough of UGA stop codons by selenocysteine-specific tRNA (tRNASec) enables the synthesis of selenoproteins. Seryl-tRNA synthetase (SerRS) charges tRNASec with serine, which is modified into selenocysteine and delivered to the ribosome by a designated elongation factor (eEFSec in ...
ORGANISM(S): Homo sapiens 
2025-04-11 | GSE230349 | GEO
GenomicsTargeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia (RIP-seq)
Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia (RIP-seq)
PRJNA1439360 | ENA
UnknownUtilizing Selenocysteine for Expressed Protein Ligation and Bioconjugations.
Not available
S-EPMC5824972 | biostudies-literature
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