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TranscriptomicsBCL6 repression of EP300 provides a basis for rational combinatorial therapy in diffuse large B cell lymphomas.
The BCL6 transcriptional repressor is a critical oncogene in diffuse large B-cell lymphomas (DLBCL). The specific BCL6 inhibitor RI-BPI potently kills DLBCL cells. We find that RI-BPI induces a particular gene expression signature in DLBCL. In order to identify classes of drugs that might synergize ...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-24236 | biostudies-arrayexpress
TranscriptomicsLeukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2 hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large AML patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specific hypermethylation si...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-GEOD-24505 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in CEBPA mutant and CEBPA silenced AML
Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expr...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-14417 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in MDS/secondary AML and de novo AML
An increasing body of work reveals aberrant hypermethylation of genes occurring in and potentially contributing to the pathogenesis of myeloid malignancies. Several of these diseases, such as myelodysplastic syndromes (MDS), are responsive to DNA methyltransferase inhibitors. In order to determine ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-17328 | biostudies-arrayexpress
TranscriptomicsDNMT3B7 disrupts embryonic development and accelerates lymphomagenesis
Cancer cells have an altered distribution of DNA methylation and express aberrant DNA methyltransferase 3B transcripts, which encode truncated proteins. To test if a truncated DNMT3B isoform disrupts DNA methylation in vivo, we constructed transgenic mice expressing DNMT3B7, a common truncated DNMT3...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21273 | biostudies-arrayexpress
TranscriptomicsPromoter hypermethylation in MLL-r leukemia: biology and therapeutic targeting
MLL-r infant acute lymphoblastic leukemia (ALL) has largely unclear oncogenesis. It has been shown unrelated to copy number change or mutations in the tyrosine kinome. We therefore, explored the possible role of genome wide CpG island hypermethylation in MLL-r infant ALL. We employed the HpaII-ti...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-19671 | biostudies-arrayexpress
TranscriptomicsDNA Methyltransferase 1 and DNA Methylation Patterning Contribute to Germinal Center B-Cell Differentiation
We performed DNA methylation (HELP) and gene expression profiling in 17 samples of purified Germinal center B cells (GCBs) and Naive B cells (NBC). We performed supervised analysis using HELP data and defined DNA methylation signature differentiting 2 subgroups of B cvells. Study included purifica...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31671 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation profiling of Acute Myeloid Leukemia
We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patien...
ORGANISM(S): Homo sapiens 
2010-01-12 | E-GEOD-18700 | biostudies-arrayexpress
TranscriptomicsCell of origin influences molecular and functional properties of murine induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here, we show that iPSCs obtained from fibrobla...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22827 | biostudies-arrayexpress
TranscriptomicsDNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma
We performed DNA methylation (HELP) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL were assigned to the 69 DLBCL cases. ...
ORGANISM(S): Homo sapiens 
2010-09-03 | E-GEOD-23967 | biostudies-arrayexpress
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