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TranscriptomicsGenome-wide DNA methylation in normal and IUGR pancreatic islets
Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-16839 | biostudies-arrayexpress
TranscriptomicsA high resolution map of segmental DNA copy number variation in the mouse genome
Submicroscopic (< 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. CNVs have been detected in diverse species, including mice and humans. Published...
ORGANISM(S): Mus musculus 
2006-11-20 | E-GEOD-5805 | biostudies-arrayexpress
TranscriptomicsNimblegen 385K array CGH on NCI-60 cancer cell lines
The NCI-60 cancer cell lines have been used for studying cancer pathogenesis and for drug discovery. This dataset adds to the growing number of datasets on various genomic platforms that have been made public on Cellminer (http://discover.nci.nih.gov/cellminer/) 61 cell lines (including PR:DU145 and...
ORGANISM(S): Homo sapiens 
2011-10-23 | E-GEOD-30291 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human samples with deletions of 16p11.2p12.2 or duplication/triplication of 16p11.2p12.2 to identify the breakpoints
Array CGH was performed to identify the breakpoints in 3 cases with deletions of 16p11.2p12.2 and 1 case with a duplication/triplication of 16p11.2p12.2.
ORGANISM(S): Homo sapiens 
2007-09-01 | E-TABM-286 | biostudies-arrayexpress
TranscriptomicsGenotyping of two patients with microdeletions of 16p11.2p12.2 to refine the breakpoint locations
Whole genome genoyping/copy-number analysis was performed on two patients with microdeletions of 16p11.2p12.2 to refine the breakpoint locations.
ORGANISM(S): Homo sapiens 
2007-09-01 | E-MEXP-1148 | biostudies-arrayexpress
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