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TranscriptomicsTranscription profiling of mouse skeletal muscle overexpressing PPARalpha
This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link betw...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5777 | biostudies-arrayexpress
ProteomicsPalmitoylation couples insulin hypersecretion with β-cell failure in diabetes
Hyperinsulinemia often precedes type 2 diabetes but its role in disease progression is unknown. Palmitoylation, a protein modification implicated in regulated exocytosis, is reversed by acyl-protein thioesterase 1 (APT1). We found altered APT1 biology in pancreatic islets from humans with type 2 dia...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-05 | PXD038554 | Pride
Proteomics Palmitoylation Pancreatic islet Insulin Diabetes 
ProteomicsEndothelial ether lipids link blood vessels to neurodegeneration
Vascular disease contributes to neurodegeneration, which is associated with decreased blood pressure in older humans. Plasmalogens, ether phospholipids produced by peroxisomes, are decreased in Alzheimer’s disease, Parkinson’s disease and other neurodegenerative disorders. Here we show that endothel...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024116 | Pride
Mouse Q-exactive Phospholipids/biosynthesis Glycerophospholipids Vascular biology/endothelial cells Plasmalogens Peroxisomes 
MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
TranscriptomicsMetabolic control of adult neural stem cell activity by FASN-­dependent lipogenesis
Mechanisms controlling the proliferative activity of neural stem/progenitor cells (NSPCs) play a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (FASN), the key enzyme o...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-27391 | biostudies-arrayexpress
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