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MetabolomicsFunctional study of chicken seminal plasma based on metabolomics
By using metabolomics technology, the molecular changes of seminal plasma over time under 4°C liquid preservation conditions were analyzed, and candidate biomarkers related to the functional decline of semen were screened out.
2026-04-29 | MTBLS14407 | MetaboLights
MetabolomicsSeminal lipid depletion and gut microbiome–metabolome alterations in men with gonadotropin-treated idiopathic hypogonadotropic hypogonadism: an integrated multi-omics study
This study investigated seminal plasma lipid alterations and gut microbiome–metabolome changes in men with gonadotropin-treated idiopathic hypogonadotropic hypogonadism. Seminal plasma metabolomics, fecal metagenomic sequencing, and fecal metabolomics were performed in patients and healthy controls....
2026-07-20 | MTBLS15080 | MetaboLights
MetabolomicsUntargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men: A noninvasive detection of spermatogenesis
Male factor infertility is involved in almost half of all infertile couples. Lack of the ejaculated sperm owing to testicular malfunction has been reported in 6-10% of infertile men, a condition named nonobstructive azoospermia (NOA). In this study, we investigated untargeted metabolomic profiling o...
2018-04-19 | MTBLS420 | MetaboLights
TranscriptomicsSeminal plasma and transforming growth factor-β regulate gene expression in human Ect1 ectocervical epithelial cells
In this study we examined the influence of seminal plasma on gene expression in human Ect1 ectocervical epithelial cells, and the extent to which recombinant TGFβ3 elicits comparable changes. Ect1 cells were incubated with recombinant human TGFβ3 (5 ng/ml), 10% pooled human seminal plasma (v/v), or ...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-35830 | biostudies-arrayexpress
MetabolomicsDeciphering metabolomic alterations in seminal plasma of crossbred (Bos taurus X Bos indicus) bulls through comparative deep metabolomic analysis
The incidence of sub-fertility is higher in crossbred bulls compared to zebu bulls. In the present study, we analysed the metabolomic profile of seminal plasma from crossbred and zebu bulls and uncovered differentially expressed metabolites between these two breeds. Using a high-throughput LC-MS/MS-...
2021-12-22 | MTBLS1642 | MetaboLights
MetabolomicsMetabolomic analysis of seminal fluids in oligoasthenospermia individuals

In this study, we systematically characterized the metabolic signatures of oligoasthenospermia individuals and health controls using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Additionally, we performed functional validation of specific differential metabolites ...

2025-07-14 | MTBLS12711 | MetaboLights
TranscriptomicsSystematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility
Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs in the seminal plasma of infertile males. In this study, we systematically investigated the profiles of seminal plasma piRNAs in infertile males to identify piRNAs that are altered during infe...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-78131 | biostudies-arrayexpress
MetabolomicsMetabolomic Analysis of Cauda Epididymal Fluid in Yaks and Cattle

The epididymis is the primary organ responsible for sperm maturation, with its caudal region serving as the primary storage site for mature sperm. The unique small molecule metabolites present in the cauda epididymal fluid not only facilitate the long-term storage of sperm but also ensure their s...

2025-09-29 | MTBLS13067 | MetaboLights
ProteomicsRaw dataset of seminal plasma proteomic of nellore bulls
These data show the proteomic profile of the seminal plasma of young Nelore bulls with an average age of 21.7 months and the genetic ontology of the identified proteins.
ORGANISM(S): Cellular Organisms 
2024-01-29 | PXD048943 | JPOST Repository
TranscriptomicsQuantitation of microRNAs in seminal fluid from men with and without prostate cancer
The objective of this study was to determine whether prostate cancer-associated miRNAs are present in seminal fluid and, if so, evaluate their diagnostic potential. Small RNA sequencing was used to profile and compare miRNAs in the non-sperm cellular fraction of seminal fluid from men with biopsy-pr...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56686 | biostudies-arrayexpress
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