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ProteomicsSeptin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function
Here, we investigated mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development including asymmetric ce...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-28 | MSV000089327 | MassIVE
ProteomicsShigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation
We demonstrate that OspC effectors enable S. flexneri to evade septin cage entrapment. Mechanistically, OspC catalyzes ADP-riboxanation of SEPT9 at Arg561, a critical site essential for stabilizing septin hetero-oligomers. Notably, ADP-riboxanation or mutation of Arg561 impairs septin polymerization...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070327 |
GenomicsSeptin 9 over expression in MCF7
Septin 9 over expression in MCF7
PRJNA489270 | ENA
ProteomicsCyclophilin A isomerization of Septin 2 mediates abscission during cytokinesis
The isomerase activity of Cyclophilin A is important for midbody abscission during cell division, however to date, midbody substrates remain unknown. In this study, we report that the GTP-binding protein Septin 2 interacts with Cyclophilin A. We highlight a dynamic series of Septin 2 phenotypes at t...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042822 | Pride
Human Cancer Cyclophilin a Cytokinesis Septin 2 K562 cells 
ProteomicsQuantitative analysis of septin Cdc10 & Cdc3-associated proteome during stress response in the fungal pathogen Cryptococcus neoformans
Cryptococcus neoformans is a type of pathogenic fungi that can cause infections in people with weakened immune systems. This fungal pathogen can survive in the body by growing at the host's body temperature (37\'b0C), forming a carbohydrate capsule, and producing melanin. When Cryptococcus neoforman...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2024-10-28 | PXD052407 | Pride
Cryptococcus neoformans Septin Co-ip 
ProteomicsIsolation and MS characterisation of recombinant human septin octameric complexes containing distinct SEPT9 isoforms
Native human septins form heterooctameric complexes containing different SEPT9 isoforms. To enable studies of SEPT9 function, we established a protocol for the isolation of recombinant human octamers harboring distinct SEPT9 isoforms. Mass spectrometry analysis is used to assess the purity, integrit...
ORGANISM(S): Homo sapiens (Human) 
2021-07-27 | PXD023857 | Pride
Human septins Lc-msms Recombinant septin complex Sept9 
ProteomicsProteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in breast cancer cells
Septins are a family of multimeric GTP-binding proteins, which are abnormally expressed in cancer. Septin 9 (SEPT9) is an essential and ubiquitously expressed septin with multiple isoforms, which have differential expression patterns and effects in breast cancer cells. It is unknown, however, if SEP...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD012977 | Pride
Breast cancer Septin interactome Septins Sept9 
GenomicsGenetic determinants that permit growth without the core septin Cdc12 in Cryptococcus neoformans
Genetic determinants that permit growth without the core septin Cdc12 in Cryptococcus neoformans
PRJNA1399418 | ENA
GenomicsDifferential gene expression profiles by septin 2 suppression and TNF-a treatment in human microvascular endothelial cells
Differential gene expression profiles by septin 2 suppression and TNF-a treatment in human microvascular endothelial cells
PRJNA670735 | ENA
TranscriptomicsGenetic determinants that permit growth without the core septin Cdc12 in Cryptococcus neoformans
Septins are conserved cytoskeletal GTPases that regulate morphogenesis, cytokinesis, and cell-surface organization in fungi. In most model and pathogenic yeasts, including Saccharomyces cerevisiae and Candida albicans, core septin subunits such as Cdc3 and Cdc12 are essential and their loss results ...
ORGANISM(S): Cryptococcus neoformans 
2026-01-12 | GSE315847 | GEO
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