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MetabolomicsRare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism

We investigated the cumulative contribution of rare, exonic genetic variants on the concentration of 1,487 metabolites and 53,714 metabolite ratios in urine by performing gene-based tests based on 226,233 variants from up to 4,864 participants of the German Chronic Kidney Disease (GCKD)...

2021-03-09 | MTBLS284 | MetaboLights
ProteomicsEpigenetic Control of Drought Acclimation in Sorghum (EPICON)
Two cultivars of sorghum were examined from a study performed at the Kearney Research Station in California; 1) a pre-flowering drought tolerant, post-flowering drought susceptible cultivar RTx430 and 2) a pre-flowering drought susceptible, post-flowering drought-tolerant cultivar BTx642. These dat...
ORGANISM(S): Sorghum Bicolor (ncbitaxon:4558) 
2017-10-23 | MSV000081639 | MassIVE
TranscriptomicsEffects of aging, primary osteoporosis, and cellular senescence on Human Mesenchymal Stem Cells
This SuperSeries is composed of the following subset Series: GSE35955: Effects of aging on Human Mesenchymal Stem Cells GSE35956: Effects of Primary Osteoporosis and Advanced Age on Human Mesenchymal Stem Cells GSE35957: Effects of Cellular Senescence on Human Mesenchymal Stem Cells GSE35958: Effect...
ORGANISM(S): Homo sapiens 
2012-02-22 | E-GEOD-35959 | biostudies-arrayexpress
UnknownAltered functional network topology correlates with clinical measures in very early-stage, drug-naive Parkinson's disease.
Not available
S-EPMC6589361 | biostudies-literature
TranscriptomicsUsing ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells
We compared 12 different cell populations, including embryonic stem cells before and during differentiation into embryoid bodies as well as various types of normal and tumor cells to determine if pluripotent vs. differentiated cell types use different mechanisms to establish their transcriptome. We ...
ORGANISM(S): Mus musculus 
2008-03-31 | E-GEOD-10504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 weeks-old R6/2 vs. control animals
This SuperSeries is composed of the following subset Series:; GSE9803: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice (set 1); GSE9804: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice (set 2) Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9857 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatal samples from wildtype, Hdh/Q80 animals
This SuperSeries is composed of the following subset Series:; GSE9375: Striatal gene expression data from 12 months-old Hdh4/Q80 mice and control mice. GSE9857: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice; GSE10202: Striatal gene expression data from 22-month-old CHL2 ...
ORGANISM(S): Mus musculus 
2008-05-21 | E-GEOD-10263 | biostudies-arrayexpress
GenomicsMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight in the function of this unique histone variant in embryonic and adult stem cells. Knockdown of macroH2A...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35087 | biostudies-arrayexpress
TranscriptomicswuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data
Copy number variants (CNVs) are currently defined as genomic sequences that are polymorphic in copy number and range in length from 1,000 to several million base pairs. Among current array-based CNV detection platforms, long-oligonucleotide arrays promise the highest resolution. However, the perfo...
ORGANISM(S): Mus musculus 
2008-03-11 | E-GEOD-10511 | biostudies-arrayexpress
TranscriptomicsConditional ablation of the Notch2 receptor in the ocular lens
Notch signaling is essential for proper lens development, however the specific requirements of individual Notch receptors has not been previously investigated. Here we report the lens phenotypes of Notch2 conditionally mutant mice, which exhibited severe microphthalmia, reduced pupillary openings, d...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-31643 | biostudies-arrayexpress
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