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TranscriptomicsTranscription profiling of mouse NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR)PKR
Global analysis of gene expression in NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR).
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-682 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of the eukaryotic-type ser/thr kinase PknB in Staphylococcus aureus
The function of the Staphylococcus aureus eukaryotic-like serine/threonine protein kinase PknB was investigated by transcriptome analysis using DNA-microarray technology and biochemical assays. The transcriptional profile reveals a strong regulatory impact of PknB on the expression of genes encoding...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2010-05-05 | E-GEOD-15346 | biostudies-arrayexpress
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
GenomicsSerine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma
Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma
PRJNA716269 | ENA
TranscriptomicsTranscription profiling of human NIH 3T3 inducible cell line to study the role of PKR in regulating gene expression
PKR is an interferon induced serine/threonine protein kinase, that is activated by double stranded RNA. PKR plays an important role in the antiviral defense by interferon. In addition to its role in translation, PKR participates in several signaling pathways to transcription. The goal of this experi...
ORGANISM(S): Mus musculus 
2004-01-30 | E-MEXP-50 | biostudies-arrayexpress
ProteomicsThe external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth
PknB is an essential serine/threonine protein kinase required for mycobacterial cell division and cell wall biosynthesis. Here we demonstrate that over-expression of the external PknB_PASTA domain in mycobacteria results in delayed regrowth, accumulation of elongated bacteria and increased sensitivi...
ORGANISM(S): Mycobacterium smegmatis 
2018-03-13 | PXD002120 | Pride
Muropeptides Mycobacterium tuberculosis Pasta domain Magnesium Pknb Serine/threonine protein kinase 
ProteomicsRegulation of Glycogen Synthase kinase 3beta by phosphorylation and O-beta-linked N-acetylglucosaminylation: implications on tau protein phosphorylation
Glycogen synthase kinase 3 (GSK3) plays a pivotal role in signaling pathways related to insulin metabolism and in the pathogenesis of Alzheimer s disease (AD) and other neurodegenerative disorders. More particularly, the GSK3beta isoform is involved in AD-associated tau pathology as one of the major...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-09 | MSV000094049 | MassIVE
TranscriptomicsThe role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice
AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and...
ORGANISM(S): Mus musculus 
2012-11-19 | E-GEOD-31150 | biostudies-arrayexpress
ProteomicsIdentification of Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) protein partners using Tandem Affinity Purification and Mass Spectrometry
According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as potential targets for effective depression therapy. The aim of...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-19 | MSV000091093 | MassIVE
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