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MetabolomicsImpaired Glycolysis-Derived Serine Metabolism as a Key Driver of Podocyte Injury with Senescence

Chronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence, focusing on the role of phosphoglycerate kina...

2025-08-23 | MTBLS12883 | MetaboLights
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Targeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7832 | MetaboLights
TranscriptomicsPhosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett Syndrome. As a chromatin associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. While neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been repor...
ORGANISM(S): Mus musculus 
2009-02-10 | E-GEOD-14715 | biostudies-arrayexpress
MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
GenomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (ChIP-seq)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21939 | biostudies-arrayexpress
GenomicsBromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells
Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with Bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-33281 | biostudies-arrayexpress
MetabolomicsOxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Not available
ORGANISM(S): Mus musculus 
ST002280 | MetabolomicsWorkbench
TranscriptomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (Exon)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-23 | E-GEOD-22184 | biostudies-arrayexpress
TranscriptomicsRole of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling
In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser1...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-28912 | biostudies-arrayexpress
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