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TranscriptomicsTranscription profiling of E. coli MG1655 treated with serine hydroxamate
For over 30 years, serine hydroxamate has been used to chemically stimulate a stringent response in Escherichia coli and other bacteria. These studies have elucidated numerous characteristics of the classical stringent response beyond the simple cellular response to an amino acid shortage, including...
ORGANISM(S): Escherichia coli 
2009-08-25 | E-GEOD-17506 | biostudies-arrayexpress
ProteomicsProtease activity profiling of ovarian clear cell carcinoma
Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective molecularly targeted therapies; efforts to define drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among potential targets are secreted proteases, enzyme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087385 | MassIVE
TranscriptomicsThe comparison of gene expression profile in the amygdalae between the wild-type and neuropsin knock-out mice
Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. A serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the strength of EphB2/NMDA receptor interaction controlling the e...
ORGANISM(S): Mus musculus 
2011-05-13 | E-GEOD-27088 | biostudies-arrayexpress
GenomicsIntracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity
Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity
PRJNA1282155 | ENA
GenomicsKnockdown of serine protease PRSS23 decreased FGF2 expression in gastric cancer
Knockdown of serine protease PRSS23 decreased FGF2 expression in gastric cancer
PRJNA842019 | ENA
TranscriptomicsSerine protease-mediated wounding identifies localized epidermal wound response genes in Drosophila melanogaster
We have used trypsin-mediated wounding to amplify the transcriptional response to clean puncture wounding. We studied the transcriptional response of clean puncture wounding and trypsin puncture wounding in relation to unwounded wild-type late-stage embryos. Trypsin puncture wounding generally incr...
ORGANISM(S): Drosophila melanogaster 
2013-08-12 | E-MEXP-3755 | biostudies-arrayexpress
TranscriptomicsExpression in HepG2 cells with overexpression of TMPRSS6 or its mutant version.
TMPRSS6 is a type II transmembrane serine protease and is revealed by our work to be part of a low-iron sensing pathway. When animal gets iron deficient, TMPRSS6 is required to shut off hepcidin gene, so as to allow iron to be uptaken from GI tract. The mutant mouse, which was generated by ENU mutag...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10591 | biostudies-arrayexpress
ProteomicsD. magna CT448 protease specificity
Mass developments of toxin-producing cyanobacteria are frequently observed in freshwater ecosystems due to eutrophication and global warming. These mass developments can partly be attributed to cyanobacterial toxins, such as protease inhibitors (PIs), which inhibit digestive serine proteases of Daph...
ORGANISM(S): Daphnia magna 
2018-10-04 | PXD010978 | Pride
Ct448 pics protease specificity 
TranscriptomicsKnockdown of serine protease PRSS23 decreased FGF2 expression in gastric cancer
Serine proteases dysregulation has been considered to be closely associated with the inflammatory response and tumor progression. As a novel serine protease, the biological function of PRSS23 is rarely studied in cancers. In this study, we explored the biological function of PRSS23 in GC by RNA sequ...
ORGANISM(S): Homo sapiens 
2022-05-31 | GSE204725 | GEO
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
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