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Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
Alkaline pH stress invokes in S. cerevisiae a potent and fast transcriptional response that includes many genes repressed by glucose. Certain mutants in the glucose-sensing and response pathways, such as those lacking the Snf1 kinase, are sensitive to alkalinization. We show that addition of glucose...
ORGANISM(S): Saccharomyces cerevisiae 
Patients with conventional mantle cell lymphoma (MCL) show an aggressive clinical behavior. However, cases fulfilling the WHO criteria for MCL, but that remain asymptomatic without treatment, have been reported. In an attempt to understand this heterogeneity, we have compared 17 typical cases of MCL...
ORGANISM(S): Homo sapiens 
Menstrual blood-derived mesenchymal stromal cells (MenSCs) are a promising alternative source of MSCs for clinical applications due to their unique advantages, including easy isolation and high proliferative capacity. They possess immunomodulatory and regenerative capabilities, interacting with immu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-22 | MSV000096909 | MassIVE
Microarrays analysis identifies WNT16in senescent fibroblasts. To identify genes expressed in replicative senescence, microarray experiments were conducted in which we compared the RNA expression profile of young MRC5 fibroblasts at population doubling 28 (PDL28) and replicative senescent MRC5 fibro...
ORGANISM(S): Homo sapiens 
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