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MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
ProteomicsComparative proteomics of Mycoplasma pneumoniae clinical isolates
The human respiratory tract pathogen M. pneumoniae is one of the best characterized minimal bacterium. Until now, two main groups of clinical isolates of this bacterium have been described (types 1 and 2), differing in the sequence of the P1 adhesin gene. Here, we have sequenced the genomes of 23 cl...
ORGANISM(S): Mycoplasma pneumoniae M129-B7 
2016-07-05 | PXD002501 | Pride
Proteomics Mycoplasma pnemoniae 
ProteomicsDefining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium
Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found, that small ORFs (smORFs; <100 residues), accounting for 10% of all ORFs, are the most frequently essential genomic components (53%)....
ORGANISM(S): Mycoplasma pneumoniae M29 
2015-03-03 | PXD001611 | Pride
Minimal genome Small proteins Non-coding rnas 
UnknownPrevalence of meeting 24-Hour Movement Guidelines from pre-school to adolescence: A systematic review and meta-analysis including 387,437 participants and 23 countries.
Not available
S-EPMC9338333 | biostudies-literature
UnknownKosakonia cowanii Ch1 Isolated from Mexican Chili Powder Reveals Growth Inhibition of Phytopathogenic Fungi.
Not available
S-EPMC10384288 | biostudies-literature
ProteomicsThe lysosomal proteome of senescent cells contributes to the senescence-associated secretome
Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age-related diseases. The senescence-associated secretory phenotype (SASP) is considered the main pathological feature of senescent cells, however, little is known about the mechanism of secretion of SAS...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD022492 | Pride
Lysosomes Senescence Macroautophagy Protein degradation. Chaperone-mediated autophagy 
UnknownSynthesis and anticancer activity of carbosilane metallodendrimers based on arene ruthenium(ii) complexes.
Not available
S-EPMC4863959 | biostudies-literature
ProteomicsEffect of menstrual blood-derived mesenchymal stromal cell secretomes on macrophage polarization: therapeutic insights
Menstrual blood-derived mesenchymal stromal cells (MenSCs) are a promising alternative source of MSCs for clinical applications due to their unique advantages, including easy isolation and high proliferative capacity. They possess immunomodulatory and regenerative capabilities, interacting with immu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-22 | MSV000096909 | MassIVE
UnknownStudents' perceptions and experiences of an online well-being programme: a phenomenological study protocol.
Not available
S-EPMC10928734 | biostudies-literature
ProteomicsMASS SPECTROMETRY ROADMAPS TO NAIVE PLURIPOTENCY
Pluripotency can be maintained in the naïve state through manipulation of ERK and WNT signalling (2i), shielding embryonic stem cells (ESCs) from inductive cues. Alternatively, inhibiting CDK8/19 (CDK8/19i), a repressor of the Mediator co-activator complex, directly stimulates super-enhancer activit...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-10 | PXD018694 | Pride
Phosphoproteomics Mouse stem cells Proteomics 
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