Sort   by:  
 Page size 
ProteomicsEarly response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom
Manifestations of local tissue damage, such as hemorrhage and myonecrosis, are among the most dramatic effects of envenomation by viperid snakes. Snake venom metalloproteinases (SVMPs) of the P-III class are main players of the hemorrhagic effect due to their activities in promoting blood vessel dis...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-25 | PXD011274 | Pride
C2c12 myotubes  hf3  snake venom metalloproteinase  peptidomics  proteomics 
ProteomicsComparative analysis of high molecular mass subproteomes of Bothrops snake venoms
Snake venoms are extremely active biological secretions containing primarily various classes of enzymes. The genus Bothrops comprises various pit viper species that represent the most medically significant taxa in Central and South America, accounting for more human envenomations and fatalities than...
ORGANISM(S): Bothrops neuwiedi Bothrops moojeni Bothrops insularis Bothrops cotiara Bothrops jararacussu Bothrops leucurus Acyrthosiphon pisum (Pea aphid) Bothrops jararaca (Jararaca) (Bothrops jajaraca) Bothrops brazili 
2019-03-05 | PXD012088 | Pride
Snake venom Mass spectrometry Enzymes Proteome 
ProteomicsSystemic effects of hemorrhagic snake venom metalloproteinases: untargeted peptidomics to explore the pathodegradome of plasma proteins
In this study we investigated the proteolysis of human plasma proteins by HF3, an hemorrhagic metalloproteinase from B. jararaca venom. For this purpose, approaches for the depletion of the most abundant proteins and for the enrichment of low abundant proteins of human plasma were used to minimize t...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027997 | Pride
Bothrops  snake venom  hemorrhagic factor 3 (hf3)  human plasma  degradome 
ProteomicsThe distinct N-terminomes of Bothrops jararaca newborn and adult venoms.
In this study we applied the Terminal Amine Isotopic Labeling of Substrates (TAILS) technology to characterize the natural N-terminome of newborn and adult Bothrops jararaca venoms.
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2021-05-15 | PXD022696 | Pride
Bothrops jararaca  snake venom  n-terminome  proteolytic processing  tails. 
ProteomicsVenom profiling of the insular species Bothrops alcatraz: characterization of proteome, glycoproteome, and N-terminome using Terminal Amine Isotopic Labeling of Substrates.
In this study we applied mass spectrometric approaches to characterize the proteome and glycoproteome of B. alcatraz venom, and to show for the first time the use of the TAILS method to profile a snake venom N-terminome.
ORGANISM(S): Bothrops alcatraz 
2021-01-13 | PXD021561 | Pride
Bothrops alcatraz  snake venom  proteome  glycoproteome  n-terminome  proteolytic processing 
Sort   by:  
 Page size