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TranscriptomicsTranscription profiling of rat fibroblasts transformed with HRAS and treated with the demethylating agent 5-aza-2-deoxycytidine
Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation has not yet been investigated thoroughly. To address this issue, we identified genes suppres...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-4427 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of colon carcinoma cell lines
To investigate potential differences between strong and weak oscillators at the gene expression level we carried out a transcriptome analysis for each cell line. Our results indicate that phenotypic circadian clock differences are reflected by gene expression differences both in genes of the core ...
ORGANISM(S): Homo sapiens 
2014-05-31 | E-GEOD-46549 | biostudies-arrayexpress
TranscriptomicsKaplan2013: High-Resolution, Quantitative Genetic Analysis of RNA Polymerase II
Dynamic control of gene expression is crucial for most aspects of cell physiology and at its core is RNA polymerase II (RNAPII). Using 53 RNAPII point mutants, we generated a point mutant epistatic miniarray profile (pE-MAP) comprising ~60,000 quantitative genetic interactions in Saccharomyces cere...
ORGANISM(S): Saccharomyces cerevisiae 
2013-08-06 | E-GEOD-47429 | biostudies-arrayexpress
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