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TranscriptomicsBeta cell 5’-shifted isomiRs are candidate regulatory hubs in type 2 diabetes
We performed deep sequencing of small RNA from mouse insulinoma (MIN6) cells cultured in 25mM glucose. We then developed and implemented an in-house short-read mapping strategy to analyze isomiR diversity. Profile of miRNA expression in MIN6 cells cultured in 25mM glucose.
ORGANISM(S): Mus musculus 
2013-09-10 | E-GEOD-44262 | biostudies-arrayexpress
TranscriptomicsSmall tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C
Small, non-coding RNAs control gene expression post-transcriptionally and play important roles in virus-host interactions. Within the liver, the microRNA (miRNA) miR-122 is essential for replication of hepatitis C virus (HCV), while repression of miR-148a by hepatitis B virus (HBV) may enhance tumor...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-57381 | biostudies-arrayexpress
TranscriptomicsAn integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response [miRNA-seq]
Estrogen receptor α (ERα) is an important biomarker of breast cancer severity and a common therapeutic target. Recent studies have demonstrated that in addition to its role in promoting proliferation, ERα also protects tumors against metastatic transformation. Current therapeutics antagonize ERα...
ORGANISM(S): Homo sapiens 
2016-08-19 | E-GEOD-78168 | biostudies-arrayexpress
TranscriptomicsAn integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response [RNA-seq]
Estrogen receptor α (ERα) is an important biomarker of breast cancer severity and a common therapeutic target. Recent studies have demonstrated that in addition to its role in promoting proliferation, ERα also protects tumors against metastatic transformation. Current therapeutics antagonize ERα...
ORGANISM(S): Homo sapiens 
2016-08-19 | E-GEOD-78167 | biostudies-arrayexpress
TranscriptomicsGene expression data from SOX2 knock-out 2102Ep and NTera-2 human embryonal carcinoma cell lines
SOX2 is an oncogene and a core pluripotency transcription factor. SOX2 has multiple roles in various malignancies, in the maintainance of pluripotency and during various stages of embryonic development. Human embryonal carcinoma cells express SOX2 and the loss of this results in their differentiatio...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59234 | biostudies-arrayexpress
GenomicsGlobal epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
Identifying cis-regulatory elements is important to understand how human pancreatic islets modulate gene expression in physiologic or pathophysiologic (e.g., diabetic) conditions. We conducted genome-wide analysis of DNase I hypersensitive sites, histone H3 lysine methylation marks (K4me1, K4me3, K7...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-23784 | biostudies-arrayexpress
ProteomicsOmics Reveal Far Reaching Effects of Verapamil Treatment in Subjects with Type 1 Diabetes
Proteomic data from recent onset T1D patients treated with verapamil where significant extension of the honeymoon phase was observed. Samples were depleted with MARS Hu-14 column, digested with trypsin, labeled with 11-plex TMT, then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-09 | MSV000087598 | MassIVE
TranscriptomicsscRNA-seq of human fetal intestinal ileum tissue
Here, we performed single cell RNA sequencing (scRNA-seq) of human fetal ileum tissue samples from 3 individual biological specimens ages 11.4, 14.4, and 18.9 weeks post conception. The data set is composed of over 16,000 cells from diverse intestinal lineages.
ORGANISM(S): Homo sapiens 
2021-02-22 | E-MTAB-9906 | biostudies-arrayexpress
TranscriptomicsmiR-182 and miR-10a are Key Regulators of Treg specialisation and stability during Th2 and Th1-associated Inflammation
A variety of CD4+Foxp3+ Treg cell types have been described previously, indicating molecular heterogeneity within the Foxp3+ pool of CD4+ T cells. However, the factors that shape the transcriptomic identities of different Foxp3+ Treg cells are poorly understood. To identify the molecular pathways in...
ORGANISM(S): Mus musculus 
2016-04-07 | E-GEOD-45976 | biostudies-arrayexpress
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