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MetabolomicsQuantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome

INTRODUCTION: Since the beginning of the SARS-CoV-2 pandemic in December 2019 multiple metabolomics studies have proposed predictive biomarkers of infection severity and outcome. Whilst some trends have emerged, the findings remain intangible and uninformative when it comes to n...

2024-04-23 | MTBLS7429 | MetaboLights
MetabolomicsSerum metabolomics profiling identifies new predictive biomarkers for disease severity in COVID-19 patients
Not available
ORGANISM(S): Homo sapiens 
ST002301 | MetabolomicsWorkbench
MetabolomicsBiomarker Discovery in Oral Cancer (OSMF & OSCC) and its severity

Oral squamous cell carcinoma (OSCC) is frequently the outcome of oral submucous fibrosis (OSMF), a common possibly premalignant disease. In our study, a cohort of 50 patients with OSCC and OSMF, along with 50 healthy controls, was analyzed to identify significant metabolic differences between the...

2024-10-23 | MTBLS11009 | MetaboLights
MetabolomicsMulti-0mics and Machine Learning-Based Profiling of Severity signatures in Mycoplasma Pneumoniae Infection in children

Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children. Yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify pot...

2026-01-04 | MTBLS13511 | MetaboLights
MetabolomicsValidation: Multi-Omics and Machine Learning-Based Profiling of Severity Signatures in Mycoplasma Pneumoniae Infection in Children

Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children, yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify pot...

2026-01-05 | MTBLS13504 | MetaboLights
ProteomicsIdentifying fecal host biomarkers for the presence and severity of Clostridioides difficile infection using top-down proteomics
Clostridioides difficile is a major cause of healthcare-associated diarrhea in adult patients. Laboratory diagnosis of C. difficile infection (CDI) is challenging as there is no single test combining high sensitivity and specificity, rapid turnaround time and cost efficiency. They also offer no or l...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020117 | Pride
Matrix metalloproteinase-7 Mass spectrometry Human Immunoglobulin kappa constant Biomarker discovery Free immunoglobulin light chain Stool Clostridium difficile Mouse model Proteomics Alpha-2-macroglobulin Feces Alpha-1-antitrypsin Clostridioides difficile 
ProteomicsPlasma Proteomics Reveal COVID-19 Associated Network and Severity Biomarkers
Coronavirus disease 2019 (COVID-19) has been threatening public health for the last 3 years globally. So far, the pathophysiology of the disease and therapeutic strategies have not clearly known yet. In this project, performing label-free plasma proteomics analysis, we aimed at identifying severity ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2023-03-11 | PXD031813 | Pride
Severity biomarkers Covid-19 associated network Label-free quantification Covid-19 disease Mass-spectrometry based plasma proteomics 
MetabolomicsMono-Locus and Pyramided Resistant Grapevine Cultivars Reveal Early Putative Biomarkers Upon Artificial Inoculation With Plasmopara viticola
One of the most economically important grapevine diseases is Downy mildew (DM) caused by the oomycete Plasmopara viticola. A strategy to reduce the use of fungicides to compensate for the high susceptibility of V. vinifera is the selection of grapevine varieties showing pathogen-specif...
2021-07-07 | MTBLS2876 | MetaboLights
MetabolomicsExploratory metabolomic profiling in migraine with PFO: dysregulated pathways and potential biomarkers

Background: Emerging evidence implicates patent foramen ovale (PFO) as a potential contributor to migraine through paradoxical metabolite shunting, microembolism and hypoxemia. However, systematic characterization of metabolic alterations in migraine patients with PFO (PFO-M) remains un...

2026-03-26 | MTBLS13630 | MetaboLights
GenomicsExtracellular Vesicle miRNAs as Biomarkers of Asthma Severity
Extracellular Vesicle miRNAs as Biomarkers of Asthma Severity
PRJNA1177844 | ENA
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