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MetabolomicsTime-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights
Proteomicssevoflurane exposures on neonatal and adult mice,LC-MSMS
Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has the potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits in newborn mice but not adult mice, whereas short-term or single inhalatio...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-08 | PXD037294 | Pride
Lc-msms Mice Cortex Sevoflurane 
Transcriptomicsm6A RNA methylation profiling in hippocampus of POCD mice induced by sevoflurane
Elderly patients are apt to cognitive impairment and memory loss after surgical operations. This perioperative cerebral damage named postoperative cognitive dysfunction (POCD) is profoundly affected by anesthesia. N6-methyladenosine (m6A) RNA methylation as a widely-studied epigenetic modification t...
ORGANISM(S): Mus musculus 
2021-05-31 | E-MTAB-10510 | biostudies-arrayexpress
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of sevoflurane-treated and sevoflurane-untreated U251 cells Transcriptomes
Next Generation Sequencing Facilitates Quantitative Analysis of sevoflurane-treated and sevoflurane-untreated U251 cells Transcriptomes
PRJNA795685 | ENA
GenomicsRNA sequencing of mouse after single sevoflurane exposure
RNA sequencing of mouse after single sevoflurane exposure
PRJNA638413 | ENA
GenomicsExpression data from sevoflurane anesthesia treated rat
Expression data from sevoflurane anesthesia treated rat
PRJNA578770 | ENA
ClinicalCancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia
The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.
2154097 | ecrin-mdr-crc
GenomicsTranscriptomic profile in the fetal cerebral cortex after maternal sevoflurane
Transcriptomic profile in the fetal cerebral cortex after maternal sevoflurane
PRJNA701403 | ENA
Genomics10x single cell sequencing for old mouse transcriptomes after sevoflurane exposure
10x single cell sequencing for old mouse transcriptomes after sevoflurane exposure
PRJNA922081 | ENA
GenomicsRNA sequencing of human embryonic stem cell after sevoflurane exposure
RNA sequencing of human embryonic stem cell after sevoflurane exposure
PRJNA624268 | ENA
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