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GenomicsSF3B1 Phosphorylation Prompts U2AF2 Dissociation for Widespread Control of Pre-mRNA Splicing
SF3B1 Phosphorylation Prompts U2AF2 Dissociation for Widespread Control of Pre-mRNA Splicing
PRJNA1298776 | ENA
ProteomicsRoles of the phosphorylated SF3B1 in the activated spliceosome - experiment 2
SF3B1 is essential for assembly of B-complex spliceosome and activation of the Bact complex and undergoes dynamic phosphorylation and dephosphorylation during the splicing cycle. We have recently showed that the N-terminus of SF3B1 is phosphorylated during spliceosome activation by a little studied ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-24 | PXD063162 | Pride
Sf3b1 phosphorylation Snip1 Rna splicing 
ProteomicsRoles of the phosphorylated SF3B1 in the activated spliceosome - experiment 1
SF3B1 is essential for assembly of B-complex spliceosome and activation of the Bact complex and undergoes dynamic phosphorylation and dephosphorylation during the splicing cycle. We have recently showed that the N-terminus of SF3B1 is phosphorylated during spliceosome activation by a little studied ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-24 | PXD063160 | Pride
Sf3b1 phosphorylation Snip1 Rna splicing 
GenomicsPhosphorylation of SF3B1 by CDK11 1 orchestrates spliceosome activation via SNIP1 dependent RES complex recruitment
Phosphorylation of SF3B1 by CDK11 1 orchestrates spliceosome activation via SNIP1 dependent RES complex recruitment
PRJNA1254673 | ENA
GenomicsPhosphorylation of SF3B1 by CDK11 1 orchestrates spliceosome activation via SNIP1 dependent RES complex recruitment
Phosphorylation of SF3B1 by CDK11 1 orchestrates spliceosome activation via SNIP1 dependent RES complex recruitment
PRJNA1254674 | ENA
ProteomicsCDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of gene expression. It is controlled by the spliceosome, a megadalton RNA-protein complex that assembles de novo on each pre-mRNA intron via an ordered assembly of intermediate complexes. Spliceosome activatio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-09 | MSV000089855 | MassIVE
TranscriptomicsSF3B1 Phosphorylation Prompts U2AF2 Dissociation for Widespread Control of Pre-mRNA Splicing
Reversible pre-mRNA splicing factor phosphorylation is a well-documented feature of spliceosome assembly, activation, and disassembly, yet its functional and mechanistic roles are still emerging. SF3B1, a core spliceosome subunit, is extensively phosphorylated before the first catalytic step of pre-...
ORGANISM(S): Homo sapiens 
2026-03-06 | GSE304018 | GEO
OtherPhosphorylation of SF3B1 by CDK11 1 orchestrates spliceosome activation via SNIP1 dependent RES complex recruitment
Splicing Factor 3b Subunit 1 (SF3B1), a core component of the spliceosome, undergoes dynamic phosphorylation and dephosphorylation during the splicing cycle to regulate pre-mRNA splicing. Twenty-eight threonine/proline repeats are phosphorylated by CDK11 during spliceosome activation and remain phos...
ORGANISM(S): Homo sapiens 
2026-02-24 | GSE295433 | GEO
TranscriptomicsPhosphorylation of SF3B1 by CDK11 1 orchestrates spliceosome activation via SNIP1 dependent RES complex recruitment
Splicing Factor 3b Subunit 1 (SF3B1), a core component of the spliceosome, undergoes dynamic phosphorylation and dephosphorylation during the splicing cycle to regulate pre-mRNA splicing. Twenty-eight threonine/proline repeats are phosphorylated by CDK11 during spliceosome activation and remain phos...
ORGANISM(S): Homo sapiens 
2026-02-24 | GSE295435 | GEO
ProteomicsCDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
CDK11 is a cyclin-dependent kinase with a role in transcription and RNA splicing and represents a potential target of anticancer treatment. This study investigated the interconnection between CDK11 and the p53 tumour suppressor protein. We show that blocking CDK11 functions with selective OTS964 inh...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD057524 | Pride
Human Sf3b1 Isoform Mass spectrometry P21waf1 Rna splicing Cyclin-dependent kinase 11 P21l P53 
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