Sort   by:  
 Page size 
TranscriptomicsProtracted p53-independent stimulation of p21WAF1/Cip1 fuels genomic instability by deregulating the replication licensing machinery
The cyclin-dependent kinase inhibitor p21WAF1/Cip1 is the prototype downstream effector of the tumor suppressor protein p53. Yet, evidence from human cancer and mice models, imply that p21WAF1/Cip1, under certain conditions, can exercise oncogenic activity. The mechanism behind this behavior is stil...
ORGANISM(S): Homo sapiens 
2016-05-15 | E-GEOD-62166 | biostudies-arrayexpress
ProteomicsUbiquitin-dependent degradation of p21Waf1/Cip1 is mediated by AMBRA1 to limit DNA replication stress
The cell cycle orchestrates the events that lead to cell replication and division. AMBRA1 is a scaffold factor that interacts with the E3 ubiquitin ligase DDB1-CRL4 complex to regulate the stability of Cyclin D-type proteins, key regulators of the G1-S phase transition. However, the role of AMBRA1 i...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD053083 | Pride
Ambra Dna P21 
TranscriptomicsProtracted p53-independent stimulation of p21WAF1/Cip1 fuels genomic instability by deregulating the replication licensing machinery
The cyclin-dependent kinase inhibitor p21WAF1/Cip1 is the prototype downstream effector of the tumor suppressor protein p53. Yet, evidence from human cancer and mice models, imply that p21WAF1/Cip1, under certain conditions, can exercise oncogenic activity. The mechanism behind this behavior is stil...
ORGANISM(S): Homo sapiens 
2016-05-15 | GSE62166 | GEO
UnknownHistone acetylation regulates p21WAF1 expression in human colon cancer cell lines.
Not available
S-EPMC4572185 | biostudies-literature
UnknownRad9 modulates the P21WAF1 pathway by direct association with p53.
Not available
S-EPMC1885445 | biostudies-literature
UnknownThe Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.
Not available
S-EPMC110626 | biostudies-literature
Unknownp21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.
Not available
S-EPMC1343585 | biostudies-literature
GenomicsHomo sapiens
Protracted p53-independent stimulation of p21WAF1/Cip1 fuels genomic instability by deregulating the replication licensing machinery
PRJNA263336 | ENA
GenomicsMetformin reverses a precancerous niche featuring cytoplasmic p21WAF1/CIP1-expressing hepatocytes and prevents hepatocellular carcinoma development
Metformin reverses a precancerous niche featuring cytoplasmic p21WAF1/CIP1-expressing hepatocytes and prevents hepatocellular carcinoma development
PRJNA433926 | ENA
ProteomicsCDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
CDK11 is a cyclin-dependent kinase with a role in transcription and RNA splicing and represents a potential target of anticancer treatment. This study investigated the interconnection between CDK11 and the p53 tumour suppressor protein. We show that blocking CDK11 functions with selective OTS964 inh...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD057524 | Pride
Human Sf3b1 Isoform Mass spectrometry P21waf1 Rna splicing Cyclin-dependent kinase 11 P21l P53 
Sort   by:  
 Page size