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ProteomicsThe BPAN disease protein WDR45 forms condensates with Caprin-1 to regulate stress granule disassembly
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder primarily caused by mutations in the WD repeat domain 45 (WDR45) gene. While WDR45 has traditionally been linked to autophagy, our study uncovers a previously unrecognized role for WDR45 as a cri...
ORGANISM(S): Homo Sapiens 
2025-04-14 | PXD062911 |
ProteomicsProteasome resides in and dismantles plant heat stress granules constitutively
Stress granules (SGs) are conserved reversible cytoplasmic condensates enriched with aggregation-prone proteins assembled in response to various stresses. Defects in disassembly have been associated with various neuro- and muscular degenerative diseases in humans. Plants appear to have efficient app...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-08-22 | PXD044922 | Pride
Stress granules (sg) Proteasomes Heat stress Sg disassembly 
TranscriptomicsThe Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
We recently identified ISRIB as a potent inhibitor of the integrated stress response (ISR). ISRIB renders cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (10.7554/eLife.00498). Here we show by genome-wide in vivo ribosome profiling that translation o...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-65778 | biostudies-arrayexpress
ProteomicsReversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
Cells respond to stress by blocking translation, rewiring metabolism, and forming transient mRNP assemblies called stress granules (SGs). After stress release, re-establishing homeostasis requires energy-consuming processes. However, the molecular mechanisms whereby cells restore energy production t...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-17 | PXD026060 | Pride
Srm Cdc19 Aggregation 
ProteomicsSpatio-temporal Proteomic Analysis of Stress Granule disassembly using APEX Reveals Regulation by SUMOylation and links to ALS pathogenesis
Cytoplasmic stress granules (SG) are membraneless organelles that form in response to a variety of cellular stresses by phase-separation of proteins associated with non-translating mRNAs. SG have recently been linked with neurodegeneration, including ALS, however there has been no systematic investi...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD017330 | Pride
Apex Sumoylation Proteomics Stress granules 
ProteomicsThe adaptor protein AP-3β disassembles heat-induced stress granules via 19S RP-associated deubiquitylation in Arabidopsis
To survive under adverse conditions, plants form stress granules (SGs) to temporally store mRNA and halt translation as a primary response. Dysregulation in SG disassembly can have detrimental effects on plant survival after stress release, yet the underlying mechanism remains poorly understood. Usi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-01-24 | PXD058194 | Pride
Stress granules  ap-3β  tsn1/2  19s rp  deubiquitylation 
UnknownASPL couples the assembly of stress granules with their VCP-mediated disassembly.
Not available
S-EPMC12506973 | biostudies-literature
UnknownSpatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Not available
S-EPMC7816607 | biostudies-literature
UnknownModulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose.
Not available
S-EPMC5343430 | biostudies-literature
UnknownSARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation.
Not available
S-EPMC8983322 | biostudies-literature
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