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ProteomicsEngineering human SH2 domains for targeted phospho-proteomics
A comprehensive analysis of the phosphoproteome is essential for understanding molecular mechanisms of human diseases. However, current tools to enrich phosphotyrosine are limited in their applicability and scope. Here, we engineered new superbinder SH2 domains that enrich diverse sets of phosphotyr...
ORGANISM(S): Homo sapiens (Human) 
2023-01-13 | PXD030038 | Pride
Phosphoproteomics Synthetic biology K562 Src homology 2 domains Sh2 superbinders Mass spectrometry Human Structural biology Protein engineering Phosphotyrosine 
UnknownSH2 Domain Binding: Diverse FLVRs of Partnership.
Not available
S-EPMC7530234 | biostudies-literature
UnknownDiscovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
Not available
S-EPMC8640019 | biostudies-literature
UnknownLoops govern SH2 domain specificity by controlling access to binding pockets.
Not available
S-EPMC6590088 | biostudies-literature
UnknownProline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.
Not available
S-EPMC2810249 | biostudies-literature
UnknownDemonstration of Binding Induced Structural Plasticity in a SH2 Domain.
Not available
S-EPMC7247818 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis SH2 domain-containing gene PASTA mutant vs. wild type
The protein modules known as SH2 (Src-homology-2) domains are key players in the signal transduction of animals. Two questions arise: Do such modules exist in plants, and when did SH2 domains evolve? Here I show that the Arabidopsis genome contains three strong candidates for plant SH2 proteins (ref...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5619 | biostudies-arrayexpress
UnknownTime-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases.
Not available
S-EPMC4841779 | biostudies-literature
UnknownDetermining folding and binding properties of the C-terminal SH2 domain of SHP2.
Not available
S-EPMC8605372 | biostudies-literature
UnknownNovel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain.
Not available
S-EPMC9196127 | biostudies-literature
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