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ProteomicsEngineering human SH2 domains for targeted phospho-proteomics
A comprehensive analysis of the phosphoproteome is essential for understanding molecular mechanisms of human diseases. However, current tools to enrich phosphotyrosine are limited in their applicability and scope. Here, we engineered new superbinder SH2 domains that enrich diverse sets of phosphotyr...
ORGANISM(S): Homo sapiens (Human) 
2023-01-13 | PXD030038 | Pride
Phosphoproteomics Synthetic biology K562 Src homology 2 domains Sh2 superbinders Mass spectrometry Human Structural biology Protein engineering Phosphotyrosine 
ProteomicsPhosphorylation of the multi functional signal transducer B-cell adaptor protein (BCAP) facilitates recruitment of multiple SH2/SH3 proteins including Grb2.
B-cell adaptor protein (BCAP) is a multimodular, multi-functional signal transducer that regulates signal transduction processes in leukocytes including macrophages, B-cells and T-cells. In particular BCAP acts as a negative regulator of inflammatory signaling by the Toll-like receptors. Here we cha...
ORGANISM(S): Homo sapiens (Human) 
2019-09-16 | PXD014410 | Pride
Sh2 domains Toll-like receptors Phosphoinositide 3-kinase Human cell line hek293t bcap Phosphorylation Sh3 domains 
TranscriptomicsA Dictyostelium SH2 domain adaptor protein required for correct DIF-1 signaling and pattern formation
When developing in the light slug formation in LrrB null (lrrB-) mutants is delayed, relative to the parental strain, and the slugs are highly defective in phototaxis and thermotaxis. In the dark the mutant arrests development as an elongated mound, in a novel process we term dark stalling. The deve...
ORGANISM(S): Dictyostelium discoideum 
2011-05-31 | E-TABM-1090 | biostudies-arrayexpress
UnknownSH2 Domains: Folding, Binding and Therapeutical Approaches.
Not available
S-EPMC9783222 | biostudies-literature
UnknownEngineered SH2 Domains for Targeted Phosphoproteomics.
Not available
S-EPMC9251651 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis SH2 domain-containing gene PASTA mutant vs. wild type
The protein modules known as SH2 (Src-homology-2) domains are key players in the signal transduction of animals. Two questions arise: Do such modules exist in plants, and when did SH2 domains evolve? Here I show that the Arabidopsis genome contains three strong candidates for plant SH2 proteins (ref...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5619 | biostudies-arrayexpress
UnknownEvolution of SH2 domains and phosphotyrosine signalling networks.
Not available
S-EPMC3415846 | biostudies-literature
UnknownBTK autoinhibition analyzed by high-throughput swaps of SH2 domains.
Not available
S-EPMC12541323 | biostudies-literature
ProteomicsGST-SH2 domain of 3BP2, pull down, curdlan-stimulated BMDC
Interacting molecules with GST-fusion protein of the wild-type SH2 domain of 3BP2 (WT) or the mutant form (R486K) were precipitated usng GSH beads and identified by DIA proteome analysis.
ORGANISM(S): Mus Musculus (mouse) 
2024-11-15 | PXD054171 | JPOST Repository
UnknownSH2 domains recognize contextual peptide sequence information to determine selectivity.
Not available
S-EPMC2984226 | biostudies-literature
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