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UnknownAKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.

Background

AKI is a common sequela of coronavirus disease 2019 (COVID-19). However, few studies have focused on AKI treated with RRT (AKI-RRT).

Methods

We conducted a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to intensive care units (ICUs) at 67 hos...
S-EPMC7894677 | biostudies-literature
UnknownThrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19.

Background

Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19).

Objective

To evaluate the incidence of venous thromboembolism (VTE) and major bleeding in critically ill patients with COVID-19 and examine the observational effect of e...
S-EPMC7863679 | biostudies-literature
UnknownOutcomes of critically ill solid organ transplant patients with COVID-19 in the United States.
National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID-19) solid organ transplant (SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (I...
S-EPMC7460925 | biostudies-literature
UnknownCharacteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States.

Rationale & objective

Underlying kidney disease is an emerging risk factor for more severe coronavirus disease 2019 (COVID-19) illness. We examined the clinical courses of critically ill COVID-19 patients with and without pre-existing chronic kidney disease (CKD) and investigated the associa...
S-EPMC7501875 | biostudies-literature
UnknownPerformance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States.
Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechani...
S-EPMC8316067 | biostudies-literature
UnknownFactors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US.

Importance

The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes of critical illness from COVID-19.

Objectives

To assess factors associated with death and to examine...
S-EPMC7364338 | biostudies-literature
UnknownMachine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019.

Objectives

Critically ill patients with coronavirus disease 2019 have variable mortality. Risk scores could improve care and be used for prognostic enrichment in trials. We aimed to compare machine learning algorithms and develop a simple tool for predicting 28-day mortality in ICU patients ...
S-EPMC8378790 | biostudies-literature
UnknownAssociation of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19.

Objective

To determine whether surge conditions were associated with increased mortality.

Design

Multicenter cohort study.

Setting

U.S. ICUs participating in STOP-COVID.

Patients

Consecutive adults with COVID-19 admitted to participating ICUs between March 4 and July 1, ...
S-EPMC8926920 | biostudies-literature
UnknownModulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.
Older age is a key risk factor for adverse outcomes in critically ill patients with COVID-19. However, few studies have investigated whether preexisting comorbidities and acute physiologic ICU factors modify the association between age and death.

Design

Multicenter cohort study.

Setting

S-EPMC9426819 | biostudies-literature
UnknownIdentification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19.

Background

Subphenotypes have been identified in patients with sepsis and ARDS and are associated with different outcomes and responses to therapies.

Research question

Can unique subphenotypes be identified among critically ill patients with COVID-19?

Study design and methods

U...
S-EPMC8099539 | biostudies-literature
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