Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19.

ABSTRACT:

Background

Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19).

Objective

To evaluate the incidence of venous thromboembolism (VTE) and major bleeding in critically ill patients with COVID-19 and examine the observational effect of early therapeutic anticoagulation on survival.

Design

In a multicenter cohort study of 3239 critically ill adults with COVID-19, the incidence of VTE and major bleeding within 14 days after intensive care unit (ICU) admission was evaluated. A target trial emulation in which patients were categorized according to receipt or no receipt of therapeutic anticoagulation in the first 2 days of ICU admission was done to examine the observational effect of early therapeutic anticoagulation on survi

SUBMITTER: Al-Samkari H 

PROVIDER: S-EPMC7863679 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature