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ProteomicsHighly Active CAR T Cells that Bind to a Juxta-Membrane Region of Mesothelin and are Not Blocked by Shed Mesothelin
Identification of the major protease sites in MSLN and preparation of a monoclonal antibody, 15B6, that binds next to cell membrane at the protease sensitive region and inhibits MSLN shedding. Mab 15B6 makes very active CAR-T cells whose activity is not blocked by shed MSLN. The 15B6 CAR-T cells hav...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD033137 | Pride
Cancer Antibody Ovarian cancer Immunotherapy Pancreatic cancer 
ProteomicsStructure of Cancer Antigen Mesothelin and Its Complex with Therapeutic Antibodies
Mesothelin is a differentiation antigen expressed at high levels on the surface of many cancers; its interaction with cancer antigen CA-125 can lead to metastasis. Mesothelin has been the subject of intensive investigations as a potential cancer antigen for immunotherapy. Structures of a fragment of...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034397 | Pride
Antibody Molecular recognition Cancer marker Mesothelin Crystal structure 
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