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MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
ProteomicsStructural insights into caspase ADPR-deacylization catalyzed by a bacterial effector and host calmodulin
identification of CopC-catalyzed ADPR-deacylization modification site of caspase-3/-7/-8/-9
ORGANISM(S): Homo Sapiens 
2022-08-10 | PXD035969 |
ProteomicsFunctional Human Salivary Gland Organoids for Tissue Regeneration in Chemically Defined Culture Systems
Salivary gland dysfunction significantly impairs patients' quality of life, yet effective regenerative therapies remain clinically unavailable. In this study, we established a fully chemically defined, xeno-free three-dimensional culture system to generate functional human salivary gland organoids. ...
ORGANISM(S): Mus Musculus 
2025-07-22 | PXD066438 |
ProteomicsAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
To determine the molecular landscape of large intestinal aging, we collected 104 pieces of fresh large intestinal tissue from 26 Macaca fascicularis and performed age-, location-, and sex-resolved multi-omics analyses, including transcriptomics, proteomics, phosphoproteomics and metabolomics.
ORGANISM(S): Macaca Fascicularis Fascicularis 
2024-01-18 | PXD039361 |
ProteomicsProteomics data of colorectal cancer
Paired tumor and distant normal tissues from a cohort of 104 colon cancer patients were collected at West China Hospital and snap-frozen in liquid nitrogen. The informed consent forms were signed by the participants or their family members.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD039360 |
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