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Estrogens are steroid hormones that play critical roles in the initiation, development, and metastasis of breast and uterine cancers. The estrogen (E2) response in breast cancer cells is predominantly mediated by the estrogen receptor-alpha (ER alpha), a ligand-activated transcription factor. ER a...
ORGANISM(S): Homo sapiens 

Background: Unlike the reported CA, the abundance of fecal GCA did not significantly increase after DSS treatment in C57BL/6J mice. Hence, exogenous supplementation of GCA were given to DSS-induced colitis mice via oral gavage. We want to know whether GCA treatment at 200 mg/kg yielded fecal GCA ...

2026-05-03 | MTBLS14032 | MetaboLights

Background and aims: Elevation of conjugated primary bile acid—GCA in fecal samples was reported in IBD patients compared to healthy controls (nearly 10-fold), as well as in active ulcerative colitis (UC) patients relative to those in remission stages. Therefore we wanted to investigate the poten...

2026-05-03 | MTBLS14031 | MetaboLights
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