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ProteomicsASO-treated Shank2 KO mice total proteomic data
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061252 | Pride
Slc6a20a Shank2 Aso 
ProteomicsASO treated adult Shank2 KO mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061254 | Pride
Slc6a20a Aso Shank2 ko 
GenomicsTranscriptome analysis of Shank2-heterozygous and -homozygous mice in different brain regions
Transcriptome analysis of Shank2-heterozygous and -homozygous mice in different brain regions
PRJNA824500 | ENA
GenomicsSHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
PRJNA505528 | ENA
GenomicsTranscriptome analysis of memantine-treated Shank2 wild-type and knock-out mice
Transcriptome analysis of memantine-treated Shank2 wild-type and knock-out mice
PRJNA721409 | ENA
TranscriptomicsTranscriptome analysis of Shank2 mutant mice
Autism spectrum disorders (ASDs) are a group of developmental disorders that cause variable and heterogeneous phenotypes across three behavioral domains such as atypical social behavior, disrupted communications, and highly restricted and repetitive behaviors. In addition to these core symptoms, oth...
ORGANISM(S): Mus musculus 
2017-01-24 | GSE79824 | GEO
UnknownShank2 Regulates Renal Albumin Endocytosis.
Not available
S-EPMC4600376 | biostudies-literature
TranscriptomicsTranscriptome analysis of Shank2-heterozygous and -homozygous mice in different brain regions
Shank2 is an abundant excitatory postsynaptic scaffolding protein implicated in neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability, developmental delay, and schizophrenia. Shank2-mutant mice with a homozygous deletion of exons 6 and 7 (Shank2-HM mice) sh...
ORGANISM(S): Mus musculus 
2022-11-02 | GSE200439 | GEO
TranscriptomicsSHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
Heterozygous loss-of-function mutations in the synaptic scaffolding gene SHANK2 are strongly associated with autism spectrum disorder (ASD). To investigate their effect on synaptic connectivity, we generated cortical neurons from induced pluripotent stem cells (iPSC) derived from neurotypic and ASD-...
ORGANISM(S): Homo sapiens 
2019-02-04 | GSE122550 | GEO
GenomicsDosage-dependent differential transcriptomic changes in the prefrontal cortex of heterozygous and homozygous Shank2-mutant mice
Dosage-dependent differential transcriptomic changes in the prefrontal cortex of heterozygous and homozygous Shank2-mutant mice
PRJNA706474 | ENA
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