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GenomicsBrain transcriptome analysis of Slc6a20a heterozygous and homozygous mutant mice
Brain transcriptome analysis of Slc6a20a heterozygous and homozygous mutant mice
PRJNA796002 | ENA
TranscriptomicsBrain transcriptome analysis of Slc6a20a heterozygous and homozygous mutant mice
SLC6A20A is a proline and glycine transporter known to regulate glycine homeostasis and NMDA receptor (NMDAR) function in the brain. A previous study on Slc6a20a-haploinsufficient mice reported increases in ambient glycine levels and NMDA receptor-mediated synaptic transmission in the brain, but whe...
ORGANISM(S): Mus musculus 
2022-02-07 | GSE193387 | GEO
UnknownSlc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes.
Not available
S-EPMC8936588 | biostudies-literature
ProteomicsASO-treated Shank2 KO mice total proteomic data
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061252 | Pride
Slc6a20a Shank2 Aso 
ProteomicsASO-treated Shank3 HT mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061258 | Pride
Aso Shank3 Slc6a20a 
ProteomicsASO treated adult Shank2 KO mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061254 | Pride
Slc6a20a Aso Shank2 ko 
ProteomicsASO-treated Shank3 HT mice proteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061255 | Pride
Shank3 ht Slc6a20a Aso 
ProteomicsASO-treated Shank3 KO mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061261 | Pride
Slc6a20a Aso Shank3 ko 
GenomicsGlycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids
Glycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids
PRJNA1234530 | ENA
UnknownSLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.
Not available
S-EPMC7863395 | biostudies-literature
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