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MetabolomicsMetabolomic Profiling of the Striatum in Shank3 Knockout ASD Rats: Effects of Early Swimming Regulation

OBJECTIVE: This study aimed to investigate the regulatory impact of early swimming intervention on striatal metabolism in Shank3 gene knockout ASD model rats.

METHODS: Shank3 gene knockout exon 11-21 male 8-day-old SD rats were used as experimental subject...

2024-09-27 | MTBLS8577 | MetaboLights
Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
ProteomicsASO-treated Shank3 HT mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061258 | Pride
Aso Shank3 Slc6a20a 
ProteomicsASO-treated Shank3 HT mice proteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061255 | Pride
Shank3 ht Slc6a20a Aso 
ProteomicsASO-treated Shank3 KO mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061261 | Pride
Slc6a20a Aso Shank3 ko 
ProteomicsUnbiased proteomic analysis of postsynaptic density fractions from Shank3 mutant mice reveals brain region specific changes highly relevant to autism spectrum disorder
Disruption of the human SHANK3 gene can cause several neuropsychiatric disease entities including Phelan-McDermid syndrome (PMS), autism spectrum disorders (ASDs) and intellectual disability (ID). Although a wide array of neurobiological studies strongly supports a major role for SHANK3 in organizin...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-08 | PXD005192 | Pride
Shank3 mutants Proteomics Hippocampus Striatum Postsynaptic density (psd) 
GenomicsHypothalamus transcriptome analysis of Shank3-overexpressing mice
Hypothalamus transcriptome analysis of Shank3-overexpressing mice
PRJNA493745 | ENA
GenomicsStriatum transcriptome analysis of Shank3 knock-out/heterozygous mice
Striatum transcriptome analysis of Shank3 knock-out/heterozygous mice
PRJNA514401 | ENA
GenomicsShank3(∆C/+) mice exhibit altered transcriptomic response to swim stress
Shank3(∆C/+) mice exhibit altered transcriptomic response to swim stress
PRJNA728364 | ENA
GenomicsMedial prefrontal cortex (mPFC) transcriptome analysis of Shank3-overexpressing mice
Medial prefrontal cortex (mPFC) transcriptome analysis of Shank3-overexpressing mice
PRJNA450933 | ENA
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