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ProteomicsASO-treated Shank3 HT mice proteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061255 | Pride
Shank3 ht Slc6a20a Aso 
ProteomicsASO-treated Shank3 HT mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061258 | Pride
Aso Shank3 Slc6a20a 
TranscriptomicsTranscriptome analysis of Shank3-heterozygous and -homozygous mice in different brain regions
Shank3 is an abundant excitatory postsynaptic scaffolding proteins implicated in various neurodevelopmental and psychiatric disorders, including ASD, Phelan-McDermid syndrome, intellectual disability, and schizophrenia. Shank3-mutant mice with a homozygous deletion of exons 14-16 (Shank3-HM mice) sh...
ORGANISM(S): Mus musculus 
2022-11-02 | GSE201621 | GEO
TranscriptomicsTranscriptome analysis of Shank3-homozygous mutant and wild-type mice of different ages
Shank3 is an abundant excitatory postsynaptic scaffolding proteins implicated in various neurodevelopmental and psychiatric disorders, including ASD, Phelan-McDermid syndrome, intellectual disability, and schizophrenia. Shank3-mutant mice with a homozygous deletion of exons 14-16 (Shank3-HM mice) sh...
ORGANISM(S): Mus musculus 
2022-11-02 | GSE201853 | GEO
GenomicsTranscriptome analysis of Shank3-heterozygous and -homozygous mice in different brain regions
Transcriptome analysis of Shank3-heterozygous and -homozygous mice in different brain regions
PRJNA832324 | ENA
GenomicsTranscriptome analysis of Shank3-homozygous mutant and wild-type mice of different ages
Transcriptome analysis of Shank3-homozygous mutant and wild-type mice of different ages
PRJNA833313 | ENA
UnknownPhase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3.
Not available
S-EPMC9106668 | biostudies-literature
ProteomicsPathologically activated GABAA α3 receptors underlie autism-like features
Social deficits and repetitive behaviors define autism spectrum disorder (ASD), yet their shared underlying mechanisms remain elusive. Here we uncover a convergent pathophysiological mechanism across multiple ASD models. We found that GABAergic neurons in the dorsal raphe nucleus (DRNGABA neurons) a...
ORGANISM(S): Mus Musculus 
2026-03-27 | PXD076235 |
UnknownEx vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Not available
S-EPMC7295033 | biostudies-literature
UnknownSarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator.
Not available
S-EPMC3978259 | biostudies-literature
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