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GenomicsTGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
We examined tumours from a large cohort of patients with metastatic urothelial bladder cancer (mUC) treated with an anti–PD-L1 agent (atezolizumab) and identified major determinants of clinical response and immune escape. Whole transcriptome profiles were generated for 368 patients using TruSeq RNA ...
EGAS00001002556 | EGA
UnknownGlucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes.
Not available
S-EPMC6994137 | biostudies-literature
UnknownAnalyzing systemic lupus erythematosus publications using neural network-based multi-label classification algorithms.
Not available
S-EPMC9112627 | biostudies-literature
Genomicsena-DATASET-GNE-22-02-2018-22:43:32:906-1098 - samples
RNA was extracted from formalin-fixed and paraffin embedded tumors of a large cohort of bladder cancer patients before treatment with anti-PD-L1. RNA was sequenced using a capture based approach (exome capture, RNA access).
EGAD00001003977 | EGA
UnknownSNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans.
Not available
S-EPMC5702558 | biostudies-literature
Genomicsena-DATASET-GNE-27-07-2018-23:28:18:139-1120 - samples
Tumor DNA was extracted from formalin-fixed and paraffin embedded tumors of a large cohort of bladder cancer patients before treatment with anti-PD-L1. Normal DNA was extracted from matched PBMCs. Whole exome sequencing was performed. This is a subset of patients for which RNA sequencing is also pro...
EGAD00001004218 | EGA
ProteomicsFASN-dependent de novo lipogenesis is required for brain development
Fate and behaviour of neural progenitor cells is tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells, govern progenitor function. H...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD026110 | Pride
Fasn Human Mouse Lipogenesis Brain development Brain organoids 
UnknownImpact of Early Feeding: Metagenomics Analysis of the Infant Gut Microbiome.
Not available
S-EPMC8931315 | biostudies-literature
GenomicsData access committee handling data access requests for biomarker data from the clinical trial IMvigor210.
Data Access Committee EGAC00001000945
EGAC00001000945 | EGA
UnknownDistinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition.
Not available
S-EPMC10543719 | biostudies-literature
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