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ProteomicsDetermination of Trunk Neural Crest Cell Fate and Susceptibility to Splicing Perturbation by the DLC1-SF3B1-PHF5A splicing complex
How the ubiquitously expressed splicing factors specifically regulate neural crest (NC) development and enhance their vulnerability to splicing perturbations remain poorly understood. Here, we show that NC-specific DLC1, partnering with SF3B1-PHF5A splicing complex, are crucial for determining avian...
ORGANISM(S): Gallus Gallus 
2025-06-09 | PXD064804 |
TranscriptomicsDNA methylation profiles of mouse sperm in response to antibiotic-induced gut microbiota dysbiosis using whole-genome bisulfite sequencing
DNA methylation profile of mouse sperm from conventionally-raised mice and gut dysbiosis experienced mice were characterized using whole-genome bisulfite sequencing. Genome-wide DNA methylation changes between control and dysbiotic male�s sperm were highly comparable, with no change in DNAme globall...
ORGANISM(S): Mus musculus 
2023-11-13 | E-MTAB-10033 | biostudies-arrayexpress
UnknownEarly splicing functions of fission yeast Prp16 and its unexpected requirement for gene Silencing is governed by intronic features.
Not available
S-EPMC6546409 | biostudies-literature
TranscriptomicsDivergent genome wide transcriptional profiles from immune cell subsets isolated from SLE patients with different ancestral backgrounds
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multi-system autoimmune disease of uncertain etiology. Patients from different ancestral backgrounds demonstrate differences in clinical manifestations and autoantibody profiles. In this study we examined genome-wide transcription...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-55447 | biostudies-arrayexpress
TranscriptomicsGenetic Determinants for Susceptibility to Staphylococcus aureus Infection in A/J and C57BL/6J
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS), we found that factors on chromosomes (chr) 8, 11,...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-19668 | biostudies-arrayexpress
TranscriptomicsCryptochrome 1 regulates growth and development in Brassica through alteration in the expression of genes involved in light, phytohormone and stress signalling.
To cover a comprehensive understanding of the complex regulatory networks controlling cryptochrome 1(CRY1)-mediated photomorphogenic response in Brassica, a genome-wide differential expression analysis was performed for the 5-day-old T3 BnCRY1-OE and wild type seedlings grown under white light (100 ...
ORGANISM(S): Brassica juncea 
2014-01-10 | E-GEOD-26797 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of E. coli under different naphthoquinone treatments
E. coli MG1655 was grown in the presence of either PL (Plumbagin)/JU (Juglone)/ME (Menadione) (50 micro molar) and DMSO (0.75%)as control, and subjected to microarray analysis. The aim of the work was to understand the structure-function relationship between plumbagin and its analogues.
ORGANISM(S): Escherichia coli 
2013-08-14 | E-MEXP-3765 | biostudies-arrayexpress
UnknownIntrogressing cry1Ac for Pod Borer Resistance in Chickpea Through Marker-Assisted Backcross Breeding.
Not available
S-EPMC9039336 | biostudies-literature
TranscriptomicsIL-2 regulated genes in scurfy CD4+ T-cells
The goal of the study was to identify the genes which are regulated by Interleukin-2 in the CD4+ T cells of the scurfy mice during regulatory T-cell deficiency. Scurfy (Sf) mice bear a mutation in the forkhead box P3 (Foxp3) transcription factor, lack regulatory T-cells (Treg), develop multi-organ i...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-23398 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of transcriptome changes regulated by RANKL-RANK signaling in macrophage cell line RAW 264.7
Bone remodeling relies on the precise developmental control of osteoclasts that resorb bone and osteoblasts that lay down fresh bone matrix. The hematopoietically derived osteoclast follow a tigthly controlled genetic program where specific genes are up-regulated to aid bone resorption.Some of them ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-21639 | biostudies-arrayexpress
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